1313761-04-4

Basic information

• Product Name: 2-(3,4-dimethylphenyl)quinazolin-4(3Η)-one
• Synonyms: 2-(3,4-dimethylphenyl)quinazolin-4(3Η)-one
• CAS NO: 1313761-04-4
• Molecular Weight: 250.3
• Mol File: 1313761-04-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dimethylphenyl)quinazolin-4(3Η)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethylphenyl)quinazolin-4(3Η)-one(1313761-04-4)
• EPA Substance Registry System: 2-(3,4-dimethylphenyl)quinazolin-4(3Η)-one(1313761-04-4)

Safety Data

• Hazardous Substances Data: 1313761-04-4(Hazardous Substances Data)

Upstream product

• 6966-10-5 3,4-dimethylbenzyl alcohol 
• 28144-70-9 anthranilic acid amide 
• 1326755-21-8 2-(3,4-dimethylphenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 5973-71-7 3,4-dimethylbenzaldehyde 
• 1885-29-6 anthranilic acid nitrile 
• 201230-82-2 carbon monoxide 
• 1187386-90-8 N-phenyl-3,4-dimethylbenzamidine 

Relevant articles and documents

Ruthenium(II)-catalyzed C?C/C?N coupling of 2-arylquinazolinones with vinylene carbonate: Access to fused quinazolinones

In this work, ruthenium(II)-catalyzed C?C/C?N annulation of 2-arylquinazolinones with vinylene carbonate is reported to synthesize fused quinazolinones. This catalytic system tolerates a wide range of substrates with excellent functional-group compatibility. In this transformation, the vinylene carbonate acts as an ethynol surrogate without any external oxidant involved. Furthermore, preliminary mechanistic studies were conducted, and a plausible catalytic cycle was also proposed.

Method for photocatalytic synthesis of quinazolinone

The invention discloses a method for photocatalytic synthesis of quinazolinone. Anthranilamide and aldehyde are used as raw materials, fluorescein is used as a photocatalyst, p-toluene sulfonic acid is used as an auxiliary catalyst, and the quinazolinone is obtained through photocatalytic reaction under the irradiation of visible light. The non-metal catalyst is used, so that the reaction cost is reduced; the reaction conditions are mild, and the reaction can be completed at room temperature; and the method is simple to operate, short in reaction time, simple in post-treatment, high in product yield and more environment-friendly. The method not only has high academic value, but also has a certain industrialization prospect.

Method for synthesis of quinazolinone derivative

The invention discloses a method for synthesis of quinazolinone; the method comprises the steps of starting from o-aminobenzamide, taking water as a solvent, carrying out a ring-enlargement reaction with benzaldehyde, to generate a dihydroquinazolinone intermediate, and then under participation of a metal iridium complex, dehydrogenating to obtain the quinazolinone derivative; the reaction shows three remarkable advantages: 1) the reaction is carried out in an aqueous solution so as to reduce use of a large amount of organic solvents, and water is a cheap, green and safe solvent; 2) the reaction avoids use of highly toxic oxidants, so as to avoid damage to the environment; and 3) hydrogen gas generated from the reaction is a by-product, and has no environmental pollution; therefore, the reaction accords with the requirements of green chemistry, and has broad prospects for development.