1314013-42-7

Basic information

• Product Name: 2-(3,4-dimethoxyphenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole
• CAS NO: 1314013-42-7
• Molecular Weight: 327.34
• Mol File: 1314013-42-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dimethoxyphenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethoxyphenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole(1314013-42-7)
• EPA Substance Registry System: 2-(3,4-dimethoxyphenyl)-3-acetyl-5-(pyridin-4-yl)-2,3-dihydro-1,3,4-oxadiazole(1314013-42-7)

Safety Data

• Hazardous Substances Data: 1314013-42-7(Hazardous Substances Data)

Upstream product

• 93-47-0 N-isonicotinamido-3,4-dimethoxybenzalaldimine 
• 108-24-7 acetic anhydride 
• 54-85-3 isoniazid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Relevant articles and documents

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A new scaffold for the selective inhibition of monoamine oxidase B

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles were designed, synthesized, and tested as inhibitors against human monoamine oxidase (MAO) A and B isoforms. Several compounds, obtained as racemates, were identified as selective MAO-B inhibitors. The enantiomers of some derivatives were separated by enantioselective HPLC and tested. The R-enantiomers always showed the highest activity. Docking study and molecular dynamic simulations demonstrated the putative binding mode. We conclude that these 1,3,4-oxadiazoles derivatives are promising reversible and selective MAO-B inhibitors.