1314116-90-9

Basic information

• Product Name: 6-(biphenyl-4-yl)-5-[(2-hydroxynaphthalen-1-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• Synonyms: 6-(biphenyl-4-yl)-5-[(2-hydroxynaphthalen-1-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• CAS NO: 1314116-90-9
• Molecular Weight: 436.534
• Mol File: 1314116-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(biphenyl-4-yl)-5-[(2-hydroxynaphthalen-1-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(biphenyl-4-yl)-5-[(2-hydroxynaphthalen-1-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(1314116-90-9)
• EPA Substance Registry System: 6-(biphenyl-4-yl)-5-[(2-hydroxynaphthalen-1-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(1314116-90-9)

Safety Data

• Hazardous Substances Data: 1314116-90-9(Hazardous Substances Data)

Upstream product

• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 57477-98-2 3-biphenyl-4-yl-3-oxopropionic acid ethyl ester 
• 1314116-77-2 2-(4'-biphenylcarbonyl)-1,2-dihydrobenzo[f]chromen-3-one 
• 17356-08-0 thiourea 
• 1314117-01-5 C₂₆H₁₆O₃ 

Relevant articles and documents

Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile

In this report we describe the synthesis and biological characterization of two series of sirtuins' inhibitors (SIRTi), designed as simplification products of the previously reported SIRT1-selective inhibitor MC2141 (4). In the first series (5a-t) we report a number of 2-substituted-1,2-dihydrobenzo[f]chromen-3- ones with a marked selectivity for the inhibition of SIRT2 over SIRT1. Some of such derivatives showed also high pro-apoptotic (5i and 5l) and/or cytodifferentiating (5d, 5i, and 5o) properties in a human leukemia cell line (U937). The second group of SIRTi (6a-q) is characterized by some analogues of cambinol (3), a well known SIRTi active against the Burkitt lymphoma. Such compounds, differently from the unselective prototype, are endowed with a selective inhibition of SIRT1 over SIRT2, and, in some cases (6j, 6k, and 6q), are more efficient than 3 to induce apoptosis in U937 cells.