13142-04-6

Basic information

• Product Name: 1-(4-bromophenyl)-3-(4-methylphenyl)urea
• Synonyms: 1-(4-bromophenyl)-3-(4-methylphenyl)urea
• CAS NO: 13142-04-6
• Molecular Weight: 305.174
• Mol File: 13142-04-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(4-bromophenyl)-3-(4-methylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-3-(4-methylphenyl)urea(13142-04-6)
• EPA Substance Registry System: 1-(4-bromophenyl)-3-(4-methylphenyl)urea(13142-04-6)

Safety Data

• Hazardous Substances Data: 13142-04-6(Hazardous Substances Data)

Upstream product

• 622-58-2 p-Tolylisocyanate 
• 106-49-0 p-toluidine 
• 51625-31-1 p-Amino-phenylisocyanat 
• 106-40-1 4-bromo-aniline 
• 2493-02-9 4-bromophenyl isocyanate 
• 99-99-0 1-methyl-4-nitrobenzene 
• 59046-28-5 p-toluoyl-1H-1,2,3-benzotriazole 
• 7647-01-0 hydrogenchloride 
• 861312-74-5 (4-bromo-phenyl)-p-tolyl-carbodiimide 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 65423-89-4 triphenylarsazo-p-tolyl 
• 14917-59-0 p-bromobenzoyl azide 

Relevant articles and documents

Nitroarenes as versatile building blocks for the synthesis of unsymmetrical urea derivatives and N-Arylmethyl-2-substituted benzimidazoles

In this contribution, a fast and simple method for the synthesis of unsymmetrical urea derivatives and N-arylmethyl-2-substituted benzimidazoles was developed starting from nitroarenes. The reaction of nitroarenes and phenyl isocyanate or phenyl isothiocyanate in tin (II) chloride dihydrate/choline chloride eutectic mixture afforded the expected urea and thiourea derivatives, while the reaction of different aldehydes with o-nitroaniline or 4-methoxy-2-nitroaniline shows a markedly high preference for the obtention of N-arylmethyl-2-substituted benzimidazoles over the 2-substituted analogues. This method offers a straightforward alternative to obtain the target compounds in good to excellent yields with short reaction times employing an operationally simple experimental set-up. Graphic abstract: [Figure not available: see fulltext.] A series of unsymmetrical urea and thiourea derivatives together with 1,2-disubstituted benzimidazoles are easily obtained in good yields starting from nitroarenes employing the eutectic mixture tin (II) chloride dihydrate/choline chloride as reductive reaction media.

N - (4 - (3 - amino - 1 H - indazole - 4 - yl) phenyl) - N' - (2 - fluoro - 5 - methylphenyl) urea intermediate preparation method

The invention provides a preparation method of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea and an intermediate thereof. Specifically, the invention provides a preparation method of a borate ester compound as shown in a formula I, and the preparation method comprises the following steps: enabling a compound as shown in a formula III to react with a compound as shown in a formula IV to generate a compound as shown in a formula V, and enabling the compound as shown in the formula V to react with a boron reagent to generate the compound as shown in the formula I. The method has the characteristics of convenience in reaction, easiness in obtainment of the intermediate, high yield, high product purity of above 98.5%, low cost of raw materials and the like, and is suitable for industrial application.