1314378-12-5

Basic information

• Product Name: Bis-PEG4-PFP ester
• Synonyms: Bis-PEG4-PFP ester;PFP-PEG4-PFP;4,7,10,13-Tetraoxahexadecanedioic acid, 1,16-bis(2,3,4,5,6-pentafluorophenyl) ester
• CAS NO: 1314378-12-5
• Molecular Formula: C24H20F10O8
• Molecular Weight: 626.394832
• Mol File: 1314378-12-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DCM
• CAS DataBase Reference: Bis-PEG4-PFP ester(CAS DataBase Reference)
• NIST Chemistry Reference: Bis-PEG4-PFP ester(1314378-12-5)
• EPA Substance Registry System: Bis-PEG4-PFP ester(1314378-12-5)

Safety Data

• Hazardous Substances Data: 1314378-12-5(Hazardous Substances Data)

Usage

Description

Bis-PEG4-PFP ester is a PEG (polyethylene glycol) linker with two terminal PFP (pentafluorophenyl) ester moieties. PFP esters are activated esters that react with primary amines to form amide bonds. They have been found to be more stable than other amine reactive groups because they are less likely to undergo hydrolysis. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Uses

Used in Bioconjugation:
Bis-PEG4-PFP ester is used as a bioconjugation agent for the attachment of biomolecules to various surfaces or other molecules. The PFP ester groups provide a stable and reactive linkage, while the PEG linker enhances solubility and reduces steric hindrance.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bis-PEG4-PFP ester is used as a drug delivery agent to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG linker can be used to attach drugs to nanoparticles or other carriers, while the PFP ester groups allow for stable and specific attachment of the drug molecules.
Used in Diagnostic Imaging:
In the field of diagnostic imaging, Bis-PEG4-PFP ester can be used as a contrast agent for various imaging modalities. The PEG linker can be functionalized with imaging agents, such as fluorescent dyes or radionuclides, while the PFP ester groups allow for specific attachment to targeting molecules, improving the specificity and sensitivity of the imaging process.
Used in Tissue Engineering:
In tissue engineering, Bis-PEG4-PFP ester can be used as a component of hydrogels or other scaffolds for tissue regeneration. The PEG linker provides hydrophilicity and biocompatibility, while the PFP ester groups can be used to attach bioactive molecules, such as growth factors or extracellular matrix components, to promote tissue growth and repair.