1314378-18-1

Basic information

• Product Name: Bis-PEG2-PFP ester
• Synonyms: Bis-PEG2-PFP ester;PFP-PEG2-PFP
• CAS NO: 1314378-18-1
• Molecular Formula: C20H12F10O6
• Molecular Weight: 538.289712
• Mol File: 1314378-18-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Bis-PEG2-PFP ester(CAS DataBase Reference)
• NIST Chemistry Reference: Bis-PEG2-PFP ester(1314378-18-1)
• EPA Substance Registry System: Bis-PEG2-PFP ester(1314378-18-1)

Safety Data

• Hazardous Substances Data: 1314378-18-1(Hazardous Substances Data)

Usage

Description

Bis-PEG2-PFP ester is an amine reactive PEG linker that features two PFP ester moieties capable of forming stable amide bonds. These bonds are highly stable due to their resistance to hydrolysis. The hydrophilic PEG linker enhances the water solubility of the compound in aqueous environments, with longer PEG chains offering superior water solubility compared to their shorter counterparts.
Used in Pharmaceutical Industry:
Bis-PEG2-PFP ester is used as a conjugation agent for enhancing the stability and solubility of drug molecules. Its ability to form stable amide bonds allows for the attachment of drug molecules to the PEG linker, improving their overall stability and reducing the likelihood of hydrolysis.
Used in Bioconjugation:
Bis-PEG2-PFP ester is used as a bioconjugation agent for the attachment of biologically active molecules, such as peptides, proteins, or other therapeutic agents, to various carriers. The stable amide bond formation ensures that the conjugated molecules maintain their activity and function.
Used in Drug Delivery Systems:
Bis-PEG2-PFP ester is used as a component in the design of drug delivery systems, such as nanoparticles or liposomes, to improve the solubility and stability of encapsulated drugs. The hydrophilic PEG linker aids in the formation of stable drug delivery vehicles, enhancing the therapeutic efficacy and bioavailability of the encapsulated drugs.
Used in Diagnostic Imaging:
Bis-PEG2-PFP ester is used as a contrast agent in diagnostic imaging techniques, such as magnetic resonance imaging (MRI) or fluorescence imaging. The PEG linker can be conjugated to imaging agents, enhancing their solubility and stability in biological systems, and improving the quality of imaging results.
Used in Cosmetic Industry:
Bis-PEG2-PFP ester is used as a solubility enhancer for active ingredients in cosmetic formulations. The hydrophilic PEG linker improves the solubility of hydrophobic compounds, allowing for their effective incorporation into cosmetic products and ensuring their stability and performance.