1314412-61-7

Basic information

• Product Name: C₁₂H₁₃ClN₄O₂
• CAS NO: 1314412-61-7
• Molecular Weight: 280.714
• Mol File: 1314412-61-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₃ClN₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₃ClN₄O₂(1314412-61-7)
• EPA Substance Registry System: C₁₂H₁₃ClN₄O₂(1314412-61-7)

Safety Data

• Hazardous Substances Data: 1314412-61-7(Hazardous Substances Data)

Upstream product

• 3530-15-2 3,5-dimethyl-4H-1,2,4-triazol-4-amine 
• 111171-18-7 5-chloro-2-hydroxy-3-(hydroxymethyl)benzaldehyde 
• 17026-49-2 4-chloro-2,6-bis(hydroxymethyl)phenol 
• 106-48-9 4-chloro-phenol 

Relevant articles and documents

Mononuclear copper(ii) complexes with 3,5-substituted-4-salicylidene-amino- 3,5-dimethyl-1,2,4-triazole: Synthesis, structure and potent inhibition of protein tyrosine phosphatases

Six copper complexes of Schiff base ligands containing 3,5-substituted-4- salicylideneamino-3,5-dimethyl-1,2,4-triazole have been synthesized and well characterized. The structures of complexes 1 and 2 were determined by X-ray crystal analysis. Fluorescence and potentiometric study indicated that in the physiological pH range, one ligand was dissociated from the complexes to form 1:1 mononucleus copper complexes. The complexes potently inhibit protein tyrosine phosphatase 1B (PTP1B), T-cell protein tyrosine phosphatase (TCPTP), megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) and Src homology phosphatase 1 (SHP-1) with 3-4 fold selectivity against PTP1B over TCPTP and PTP-MEG2, and 3-9 fold over SHP-1, but display almost no inhibition against Src homology phosphatase 2 (SHP-2). Complex 1 inhibits PTP1B with a competitive model with Ki of 30 nM. Substitution with small groups at the phenyl of the ligand does not obviously influence the inhibitory ability of the complexes.