1314583-46-4

Basic information

• Product Name: C₂₂H₂₃NO₅
• Synonyms: C₂₂H₂₃NO₅
• CAS NO: 1314583-46-4
• Molecular Weight: 381.428
• Mol File: 1314583-46-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₃NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₃NO₅(1314583-46-4)
• EPA Substance Registry System: C₂₂H₂₃NO₅(1314583-46-4)

Safety Data

• Hazardous Substances Data: 1314583-46-4(Hazardous Substances Data)

Upstream product

• 4290-90-8 1-pentylisatin 

Downstream Products

• 1314583-48-6 C₂₈H₂₈N₂O₄ 

Relevant articles and documents

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

Starting from the oxindole 2a identified through a high-throughput screening campaign, a series of NaV1.7 blockers were developed. Following the elimination of undesirable structural features, preliminary optimization of the oxindole C-3 and N-1 substituents afforded the simplified analogue 9b, which demonstrated a 10-fold increase in target potency versus the original HTS hit. A scaffold rigidification strategy then led to the discovery of XEN907, a novel spirooxindole NaV1.7 blocker. This lead compound, which in turn showed a further 10-fold increase in potency, represents a promising structure for further optimization efforts.