1314882-62-6

Basic information

• Product Name: {4-[2-amino-3-(2-methoxypyridin-5-yl)pyridin-5-yl]phenyl}(morpholino)methanone
• Synonyms: {4-[2-amino-3-(2-methoxypyridin-5-yl)pyridin-5-yl]phenyl}(morpholino)methanone
• CAS NO: 1314882-62-6
• Molecular Weight: 390.442
• Mol File: 1314882-62-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: {4-[2-amino-3-(2-methoxypyridin-5-yl)pyridin-5-yl]phenyl}(morpholino)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[2-amino-3-(2-methoxypyridin-5-yl)pyridin-5-yl]phenyl}(morpholino)methanone(1314882-62-6)
• EPA Substance Registry System: {4-[2-amino-3-(2-methoxypyridin-5-yl)pyridin-5-yl]phenyl}(morpholino)methanone(1314882-62-6)

Safety Data

• Hazardous Substances Data: 1314882-62-6(Hazardous Substances Data)

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 381233-96-1 2-amino-3-iodo-5-bromopyridine 
• 163105-89-3 2-methoxy-pyridine-5-boronic acid 
• 389621-84-5 4-(morpholine-4-carbonyl)phenylboronic acid 
• 1314883-33-4 5-bromo-3-(6-methoxypyridin-3-yl)pyridin-2-amine 

Relevant articles and documents

Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines

In an effort to address potential cardiotoxicity liabilities identified with earlier frontrunner compounds, a number of new 3,5-diaryl-2-aminopyridine derivatives were synthesized. Several compounds exhibited potent antiplasmodial activity against both the multidrug resistant (K1) and sensitive (NF54) strains in the low nanomolar range. Some compounds displayed a significant reduction in potency in the hERG channel inhibition assay compared to previously reported frontrunner analogues. Several of these new analogues demonstrated promising in vivo efficacy in the Plasmodium berghei mouse model and will be further evaluated as potential clinical candidates. The SAR for in vitro antiplasmodial and hERG activity was delineated.