1314961-45-9Relevant articles and documents
Pd-Catalyzed/Iodide-Promoted α-Arylation of Ketones for the Regioselective Synthesis of Isocoumarins
Casnati, Alessandra,Maggi, Raimondo,Maestri, Giovanni,Della Ca, Nicola,Motti, Elena
, p. 8296 - 8303 (2017)
A variety of isocoumarins have been synthesized directly from 2-halobenzoates and ketones through a palladium-catalyzed α-arylation step followed by an intramolecular cyclization process. The addition of iodide anions to the reaction mixture increased yields and selectivities especially when 2-bromobenzoates were employed. This phosphine-free one-pot synthesis features a high functional group tolerance and gives access to richly decorated isocoumarins. This general methodology was successful in the total synthesis of Xyridin A, an important natural product with antibacterial and antifungal activity.
Method for synthesizing isocoumarin derivative under catalysis of silver and application of isocoumarin derivative
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Paragraph 0075-0080, (2021/05/12)
The invention belongs to the technical field of organic synthetic chemistry, and particularly relates to a method for synthesizing an isocoumarin derivative under catalysis of silver and application of the isocoumarin derivative. According to the method, 2-(phenylethynyl)benzaldehyde is taken as a model substrate, monovalent silver salt is taken as a catalyst, reaction is carried out at the temperature not lower than 30 DEG C, and the isocoumarin derivative is generated. In the field, 2-(phenylethynyl)benzaldehyde is used as a model substrate for the first time, and the isocoumarin derivative is prepared in one step under the catalytic action of the monovalent silver salt. The method is simple, convenient and efficient, the used raw materials are simple, easy to obtain and non-toxic, the steps are few, the conditions are mild, the cost is low, and the method is suitable for large-scale industrial production.
Sulfoxonium Ylides as Carbene Precursors: Rhodium(III)-Catalyzed Sequential C?H Functionalization, Selective Enol Oxygen-Atom Nucleophilic Addition, and Hydrolysis
Huang, Yuanqiong,Lyu, Xueli,Song, Hongjian,Wang, Qingmin
supporting information, p. 5272 - 5276 (2019/11/13)
Herein, we report a protocol for Rh(III)-catalyzed annulation reactions between oxazolines and sulfoxonium ylides via a sequence involving C?H activation, selective enol oxygen-atom nucleophilic addition, and hydrolysis. This practical, operationally simple protocol has a wide substrate range, excellent regioselectivity, and moderate to good yields.