1315171-93-7Relevant articles and documents
Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues
Cueva, Juan Pablo,Gallardo-Godoy, Alejandra,Juncosa, Jose I.,Vidi, Pierre A.,Lill, Markus A.,Watts, Val J.,Nichols, David E.
, p. 5508 - 5521 (2011/10/02)
To probe the space at the floor of the orthosteric ligand binding site in the dopamine D1 receptor, four methylated analogues of dihydrexidine (DHX) were synthesized with substitutions at the 7 and 8 positions. The 8α-axial, 8β-equatorial, and