1315313-35-9Relevant articles and documents
Chiral thiourea-catalyzed asymmetric michael addition of β-oxo phosphonate to nitro olefins: Convenient synthesis of optically active β-oxo phosphonates
Hu, Kuang,Liu, Tao,Lu,Liu, Yunfeng,Wang, Youming,Wu, Guiping,Zhou, Zhenghong,Tang, Chuchi
experimental part, p. 3507 - 3513 (2011/09/15)
β-Oxo phosphonates have been proven to be alternative Michael donors in Michael addition reactions to nitro olefins in the presence of cinchonine-based bifunctional thiourea, affording a direct and atom-economic approach to the efficient construction of synthetically and biologically valuable chiral acyclic α-substituted β-oxo phosphonates with high levels of enantioselectivity (up to 98 % ee). A direct and atom-economic approach to the preparation of synthetically and biologically valuable optically active acyclic α-substituted β-oxo phosphonates with high levels of enantioselectivity (up to 98 % ee)has been developed that involves chiral thiourea-catalyzed asymmetric Michael addition of β-oxo phosphonates to nitro olefins. Copyright
