13159-76-7

Basic information

• Product Name: 4-CHLORO-N-(3,4-DIMETHOXYBENZYL)ANILINE
• Synonyms: ZERENEX E/6028383;4-CHLORO-N-(3,4-DIMETHOXYBENZYL)ANILINE;N-(4-CHLOROPHENYL)-3,4-DIMETHOXYBENZYLAMINE;N-(4-chlorophenyl)-N-(3,4-dimethoxybenzyl)amine
• CAS NO: 13159-76-7
• Molecular Formula: C₁₅H₁₆ClNO₂
• Molecular Weight: 277.75
• Mol File: 13159-76-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 124 °C
• Boiling Point: 415.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.209±0.06 g/cm3(Predicted)
• PKA: 3.35±0.35(Predicted)
• CAS DataBase Reference: 4-CHLORO-N-(3,4-DIMETHOXYBENZYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-N-(3,4-DIMETHOXYBENZYL)ANILINE(13159-76-7)
• EPA Substance Registry System: 4-CHLORO-N-(3,4-DIMETHOXYBENZYL)ANILINE(13159-76-7)

Safety Data

• Hazardous Substances Data: 13159-76-7(Hazardous Substances Data)

Upstream product

• 38608-18-3 4-chloro-N-(3,4-dimethoxyphenyl)methylenebenzenamine 
• 106-47-8 4-chloro-aniline 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 

Relevant articles and documents

Synthesis and evaluation of N-analogs of 1,2-diarylethane as Helicobacter pylori urease inhibitors

Therapies based on urease inhibition are now seriously considered as the first line of treatment for infections caused by Helicobacter pylori. However, the present inhibitors are ineffective or unstable in highly acidic gastric juice. Here, we report a series of benzylanilines as effective inhibitors of H. pylori urease. Out of the obtained twenty-one compounds, N-(3,4-dihydroxybenzyl)-4-nitroaniline (4) was evaluated in detail and shows promising features for development as anti-H. pylori agent. Excellent potency against urease in both cell-free extract and intact cell was observed at low concentrations of 4 (IC50 = 0.62 ± 0.04 and 1.92 ± 0.09 μM), which showed over 29- and 54-fold increase in potency with respect to the positive control AHA. The SAR analysis revealed that protection of 3,4-dihydroxy group of 4 as methoxy or changes of 4-NO2 will result in a moderate to dramatic decrease in potency.

Sodium borohydride on wet clay: Solvent-free reductive amination of carbonyl compounds using microwaves

A solvent-flee reductive amination of carbonyl compounds by wet montmorillonite K 10 clay supported sodium borohydride is described; microwave irradiation facilitates the procedure.