131645-73-3

Basic information

• Product Name: 2-amino-3-nitrobenzoyl chloride
• Synonyms: 2-amino-3-nitrobenzoyl chloride
• CAS NO: 131645-73-3
• Molecular Weight: 200.581
• Mol File: 131645-73-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-amino-3-nitrobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3-nitrobenzoyl chloride(131645-73-3)
• EPA Substance Registry System: 2-amino-3-nitrobenzoyl chloride(131645-73-3)

Safety Data

• Hazardous Substances Data: 131645-73-3(Hazardous Substances Data)

Upstream product

• 641-70-3 3-nitrophthalic acid anhydride 
• 603-11-2 3-nitrophthalic acid 
• 77326-45-5 2-carbamoyl-3-nitrobenzoic acid 
• 606-18-8 3-nitroanthranilic acid 

Downstream Products

• 162930-60-1 2-amino-3-nitro-N-(2-oxopentyl)benzamide 
• 162930-61-2 N-(2-amino-3-nitrobenzoyl)benzeneacetamide 
• 131645-74-4 ethyl N-(2-amino-3-nitrobenzoyl)-N-propylalanine 
• 162930-59-8 2-amino-N-(3-methyl-2-oxobutyl)-3-nitrobenzamide 
• 272769-49-0 2-(1-propyl-4-piperidinyl)-1H-benzimidazole-4-carboxamide 
• 266993-72-0 3-carbamoylbenzene-1,2-diaminium dichloride 
• 1622400-70-7 C₁₃H₁₀F₃N₃O 
• 1622400-69-4 C₁₃H₁₁ClFN₃O 
• 1622400-68-3 C₁₃H₁₁F₂N₃O 
• 1622400-67-2 C₁₃H₁₁F₂N₃O 
• 1421933-32-5 C₁₄H₁₂F₃N₃O 
• 1622400-66-1 C₁₃H₁₂FN₃O 
• 1622400-65-0 C₁₃H₁₂ClN₃O 
• 1622400-64-9 C₁₄H₁₂F₃N₃O 

Relevant articles and documents

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A nine-step convergent process was developed for the synthesis of ABT-472, a benzimidazole PARP inhibitor. The identity and origin of several impurities were determined, and the process was modified to reduce or eliminate these impurities. A number of safety and control issues were investigated. The original synthesis was shortened to 9 steps and streamlined while maintaining a convergent strategy. A stable salt was selected, and control of the API solid form was established. The process was successfully scaled up to provide 8.5 kg of final product of >99% purity in 33% yield over 9 steps.

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SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS

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