131652-82-9Relevant articles and documents
Enantiospecific Construction of Quaternary Carbon Center via Intramolecular 1,3-Dipolar Cycloaddition. A New Route to Natural (-)-Mesembrine from (S)-O-Benzylglycidol
Takano, Seiichi,Samizu, Kiyohiro,Ogasawara, Kunio
, p. 1239 - 1242 (2007/10/02)
Thermolysis of the aziridine ester, obtained from (S)-O-benzylglycidol, afforded the pyrrolidine lactone bearing a quaternary carbon center stereo-specifically in a good yield via intramolecular cycloaddition of the 1,3-dipole.The adduct (11) could be converted into natural (-)-mesembrine, the major alkaloid of Sceletium namaquense, and its N-demethyl derivative via a 8 step sequence of reactions.