131657-46-0

Basic information

• Product Name: (E)-4-methyl-N-(1-methylpyrrolidin-2-ylidene)benzenesulfonamide
• Synonyms: (E)-4-methyl-N-(1-methylpyrrolidin-2-ylidene)benzenesulfonamide
• CAS NO: 131657-46-0
• Molecular Weight: 252.337
• Mol File: 131657-46-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (E)-4-methyl-N-(1-methylpyrrolidin-2-ylidene)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-methyl-N-(1-methylpyrrolidin-2-ylidene)benzenesulfonamide(131657-46-0)
• EPA Substance Registry System: (E)-4-methyl-N-(1-methylpyrrolidin-2-ylidene)benzenesulfonamide(131657-46-0)

Safety Data

• Hazardous Substances Data: 131657-46-0(Hazardous Substances Data)

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 4083-64-1 Tosyl isocyanate 
• 98-59-9 p-toluenesulfonyl chloride 
• 70-55-3 toluene-4-sulfonamide 
• 120-94-5 1-Methylpyrrolidine 
• 941-55-9 4-toluenesulfonyl azide 
• 10441-57-3 1-methyl-pyrrolidine-2-thione 

Downstream Products

• 131657-71-1 rel-(3S,1'R)-1-methyl-3-(1-hydroxybenzyl)-3-(2-propenyl)-2-(((4-methylphenyl)sulfonyl)imino)pyrrolidine 
• 131657-71-1 rel-(3S,1'S)-1-methyl-3-(1-hydroxybenzyl)-3-(2-propenyl)-2-(((4-methylphenyl)sulfonyl)imino)pyrrolidine 
• 131657-55-1 1,3-dimethyl-2-(((4-methylphenyl)sulfonyl)imino)-pyrrolidine 
• 131657-62-0 rel-(3S,1'R)-1-methyl-3-(1'-hydroxy-1'-methylbenzyl)-2-(((4-methylphenyl)sulfonyl)imino)pyrrolidine 
• 131657-56-2 1-methyl-3-allyl-2-(((4-methylphenyl)sulfonyl)imino)-pyrrolidine 
• 131657-61-9 rel-(3S,1'R)-1-methyl-3-(1'-hydroxy-2',2'-dimethylpropyl)-2-(((4-methylphenyl)sulfonyl)imino)pyrrolidine 
• 131657-59-5 rel-(3S,1'S)-1-methyl-3-(1'-hydroxy-4'-methoxybenzyl)-2-(((4-methylphenyl)sulfonyl)imino)pyrrolidine 
• 131657-59-5 rel-(3S,1'R)-1-methyl-3-(1'-hydroxy-4'-methoxybenzyl)-2-(((4-methylphenyl)sulfonyl)imino)pyrrolidine 
• 131657-57-3 rel-(3S,1'S)-1-methyl-3-(1'-hydroxybenzyl)-2-(((4-methylphenyl)sulfonyl)imino)pyrrolidine 
• 131657-57-3 rel-(3S,1'R)-1-methyl-3-(1'hydroxybenzyl)-2-(((4-methylphenyl)sulfonyl)imino)pyrrolidine 

Relevant articles and documents

N-(1-Methyl-2-pyrrolidinylidene)-p-toluene-sulfonamide: A condensation product of 4-methylphenylsulfonyl isocyanate and 1-methyl-2-pyrrolidone

The preparation of the crystalline title compound, C12H16N2O2S, which is shown to have E geometry about the imine double bond, also yields an oily Z isomer.

Photoinduced Cascade Reaction of Tertiary Amines with Sulfonyl Azides: Synthesis of Amidine Derivatives

A metal-free cascade reaction of tertiary amines with sulfonyl azides promoted by acridinium salts under blue light irradiation was developed and provided amidine derivatives in moderate to good yields. Enamine was generated from tertiary amine via single-electron transfer promoted by acridinium salts, and the following [3+2] cyclization with sulfonyl azide and CH2N2 release afforded the desired products. (Figure presented.).

Interception of amide ylides with sulfonamides: Synthesis of (: E)- N -sulfonyl amidines catalyzed by Zn(OTf)2

Through the interception of amide ylides with sulfonamides, we herein report the first general example of an intermolecular condensation reaction between sulfonamides and amides. Beyond formamides, this approach was successfully applied to a variety of lactams and linear amides, giving rise to a broad array of (E)-N-sulfonyl amidines.