13166-10-4Relevant articles and documents
Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine
Longstreet, Ashley R.,Opalka, Suzanne M.,Campbell, Brian S.,Gupton, B. Frank,McQuade, D. Tyler
, p. 2570 - 2578 (2013)
2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed nonnucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients. A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4- methylnicotinonitrile, that terminates in a dead-end crystallization is described. The route uses inexpensive, acyclic commodity-based raw materials and has the potential to enable lower cost production of nevirapine as well as other value added structures that contain complex pyridines. The route terminates in a batch crystallization yielding high purity CAPIC. This outcome is expected to facilitate regulatory implementation of the overall process.
Molybdenum hexacarbonyl-catalyzed condensation of malononitrile with ketones and aldehydes
Khusnutdinov,Shchadneva,Mayakova,Oshnyakova,Dzhemilev
, p. 683 - 686 (2013)
Molybdenum hexacarbonyl activated with pyridine or morpholine catalyzes the condensation of malononitrile with ketones and aldehydes at 140 C, which leads to alkylidenemalononitriles in 75-100% yield.
Preparation of mesoporous carbon nitride materials using urea and formaldehyde as precursors and catalytic application as solid bases
Xu, Jie,Wang, Yue,Shang, Jie-Kun,Ma, Dan,Li, Yong-Xin
, p. 221 - 229 (2017)
A series of mesoporous carbon nitride materials have been fabricated using inexpensive and eco-friendly urea and formaldehyde as precursors and mesocellular silica foam (MCF) as a template through a nanocasting approach. Several techniques, including XRD, TEM, elemental analysis, FT-IR, XPS, and CO2-TPD have been applied to characterize the physicochemical properties of the mesoCN materials, and the results show that the materials possess high surface areas (331–355?m2?g?1), relatively concentrated pore size of ca. 6?nm, and abundant and multiple nitrogen-containing species. As heterogeneous base catalysts, mesoCN materials demonstrate high catalytic activity and selectivity in both Knoevenagel condensation and transesterification reactions.
Observations of tetrel bonding between sp3-carbon and THF
Alford, Thomas P. J.,Davis, Anthony P.,Domingos, Sérgio R.,Heywood, Victoria L.,Lekanne Deprez, Siebe J.,Mooibroek, Tiddo J.,Roeleveld, Julius J.,Schnell, Melanie,Verhoofstad, Abraham,van der Vlugt, Jarl Ivar
, p. 5289 - 5293 (2020)
We report the direct observation of tetrel bonding interactions between sp3-carbons of the supramolecular synthon 3,3-dimethyl-tetracyanocyclopropane (1) and tetrahydrofuran in the gas and crystalline phase. The intermolecular contact is establishedvias-holes and is driven mainly by electrostatic forces. The complex manifests distinct binding geometries when captured in the crystalline phase and in the gas phase. We elucidate these binding trends using complementary gas phase quantum chemical calculations and find a total binding energy of -11.2 kcal mol-1for the adduct. Our observations pave the way for novel strategies to engineer sp3-C centred non-covalent bonding schemes for supramolecular chemistry.
Liquid-phase Knoevenagel reactions over modified basic microporous titanosilicate ETS-10
Goa, Yasuhide,Wu, Peng,Tatsumi, Takashi
, p. 107 - 114 (2004)
Al- and Ga-incorporated ETS-10, designated as ETAlS-10 and ETGaS-10, respectively, were synthesized by using P25 titania as a Ti source. The isomorphous substitution of Al and Ga for framework Si at the (4Si) environment was confirmed by 29Si M
Propargylamine-selective dual fluorescence turn-on method for post-synthetic labeling of DNA
Nguyen, Van Thang,Pandith, Anup,Seo, Young Jun
supporting information, p. 3199 - 3202 (2020/03/23)
We have developed a propargylamine-selective dual fluorescence turn-on system, using ylidenemalononitrile enamines, for post-synthetic DNA labeling, allowing the direct monitoring of DNA using dual emission in living cells.
Synthesis method of methylene malononitrile compounds
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Paragraph 0039-0043, (2020/04/02)
The invention discloses a synthesis method of methylene malononitrile compounds. According to the method, in the air atmosphere, a ketone compound and malononitrile are taken as raw materials, Ru/C istaken as a catalyst, the raw materials and the catalyst