131674-40-3Relevant articles and documents
Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy
Lounsbury, Nicole,Mateo, George,Jones, Brielle,Papaiahgari, Srinivas,Thimmulappa, Rajash K.,Teijaro, Christiana,Gordon, John,Korzekwa, Kenneth,Ye, Min,Allaway, Graham,Abou-Gharbia, Magid,Biswal, Shyam,Childers, Wayne
supporting information, p. 5352 - 5359 (2015/11/11)
Nrf2 activators represent a good drug target for designing agents to treat diseases associated with oxidative stress. Building upon previous work, we designed and prepared a series of heterocyclic chalcone-based Nrf2 activators with reduced lipophilicity
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
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Paragraph 00100, (2014/10/04)
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Synthesis of Pyridocyclobuten-5-one and 1-Azafulvenallene by Flash Vacuum Pyrolysis of 3-Chloroformyl-2-methylpyridine
Chou, Chin-Hsing,Wu, Cheng-Chang,Chen, Wey-Kao
, p. 5065 - 5068 (2007/10/02)
The temperature and pressure dependence of products formed on pyrolysis of 3-chloroformyl-2-methylpyridine (6) have been studied.Pyrolysis of 6 at 575 deg C and ca. 1 x 10-4 torr gives pyridocyclobuten-5-one (5) in 20percent yield.Pyrolysis of 6 at 575 and 800 deg C and under the pressure of ca. 1 x 10-2 torr give 1-azafulvenallene (7, 46percent) and 1-cyanocyclopentadiene (8, 42percent), respectively.Irradiation of 5 (λ > 300 nm) in methanol affords 2-methoxy-3-acetylpyridine (9) quantitatively.