1316759-41-7

Basic information

• Product Name: 9-ethyl-3-phenylpyrano[3,4-b]indol-1(9H)-one
• Synonyms: 9-ethyl-3-phenylpyrano[3,4-b]indol-1(9H)-one
• CAS NO: 1316759-41-7
• Molecular Weight: 289.334
• Mol File: 1316759-41-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 9-ethyl-3-phenylpyrano[3,4-b]indol-1(9H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-ethyl-3-phenylpyrano[3,4-b]indol-1(9H)-one(1316759-41-7)
• EPA Substance Registry System: 9-ethyl-3-phenylpyrano[3,4-b]indol-1(9H)-one(1316759-41-7)

Safety Data

• Hazardous Substances Data: 1316759-41-7(Hazardous Substances Data)

Upstream product

• 1202-04-6 indole-2-carboxylic acid methyl ester 
• 1316758-98-1 1-ethyl-3-iodo-1H-indole-2-carboxylic acid methyl ester 
• 1316759-26-8 C₁₉H₁₅NO₂ 
• 1316759-11-1 1-ethyl-3-phenylethynyl-1H-indole-2-carboxylic acid methyl ester 
• 534595-85-2 3-iodo-indole-2-carboxylic acid methyl ester 

Relevant articles and documents

Flexible synthesis of isomeric pyranoindolones and evaluation of cytotoxicity towards HeLa cells

A hybrid pharmacophore approach for the synthesis of isomeric pyranoindolones was achieved by employing gold(III) chloride-catalyzed cycloisomerization of alkyne-tethered indole carboxylic acids in good to excellent yield. All the synthesized compounds were evaluated for their tumor cell growth inhibitory activity against human cervix adenocarcinoma (HeLa) which revealed that three compounds exhibited activity comparable with the standard cis-platin (IC50 = 0.08 μM). Molecular docking of all the compounds in Vaccinia H1-Related (VHR) Phosphatase receptor also supported that compound 7d as the most active with a free energy of binding as ?8.27 kcal/mol. [Figure not available: see fulltext.]