13171-21-6 Usage
Description
PHOSPHAMIDON is a pale yellow to colorless oily liquid with a faint odor. It is miscible with water and is soluble in aromatic hydrocarbons. PHOSPHAMIDON decomposes on heating and releases highly toxic fumes, such as phosphorus oxides, hydrogen chloride, and nitrogen oxides. It reacts with bases (hydrolysis) and attacks metals such as iron, tin, and aluminum. It is used as a broad-spectrum insecticide and acaricide for the control of pests and vectors on crops like sugarcane, rice, citrus orchards, and cotton.
Uses
Used in Agriculture:
PHOSPHAMIDON is used as an insecticide for controlling sap-feeding insects and other pests in a wide variety of crops. It is particularly effective against sucking and boring insects and mites in a very wide range of crops and in forestry applications.
Used in Citrus, Cotton, and Deciduous Fruit and Nuts:
PHOSPHAMIDON is used as an insecticide and acaricide for the control of pests and vectors on crops like citrus, cotton, and deciduous fruit and nuts.
Used in Sugarcane and Rice:
PHOSPHAMIDON is used as a broad-spectrum insecticide and acaricide for the control of pests and vectors on crops like sugarcane and rice.
Used in Chemical Formulations:
Types of PHOSPHAMIDON formulations include soluble liquid, suspension concentrate, emulsifiable concentrate, ULV liquid, and 10% granules. These formulations are used for various applications in the agricultural industry to control pests and vectors effectively.
Air & Water Reactions
Water soluble. Hydrolyzed by alkali with a half-life at 73°F of 13.8 days at pH 7 and 2.2 days at pH 10 .
Reactivity Profile
PHOSPHAMIDON is corrosive to iron, tin and aluminum. Incompatible with alkaline preparations and should not be mixed with copper oxychloride, captan, folpet or sulfur.
Health Hazard
PHOSPHAMIDON is extremely toxic; the probable oral lethal dose for humans is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb person. It is a cholinesterase inhibitor.
Health Hazard
Phosphamidon is readily absorbed from the gastrointestinal tract, through the intact skin,
and by inhalation of spray mists and dusts. Prolonged exposures to phosphamidon cause
adverse effects and impairment on the respiratory, myocardial, and neuromuscular transmission
in animals and humans. Phosphamidon does not cause delayed peripheral neuropathy
in hens. The symptoms of poisoning include, but are not limited to, nausea, vomiting,
diarrhea, abdominal cramps, headache, dizziness, eye pain, blurred vision, constriction or
dilation of the pupils, tears, salivation, sweating, and confusion. Prolonged period of exposures
to phosphamidon cause incoordination, slurred speech, loss of refl exes, weakness,
fatigue, involuntary muscle contractions, twitching, tremors of the tongue or eyelids, and
eventually paralysis of the body extremities and the respiratory muscles, involuntary defecation
or urination, psychosis, irregular heart beat, unconsciousness, convulsions, coma,
respiratory failure or cardiac arrest leading to death. Phosphamidon has caused clastogenic
effects in the bone marrow cells of rats and mice. However, the studies are found
to be inadequate to arrive at meaningful conclusions about phosphamidon as a human
carcinogen and no data are available. The ADI for phosphamidon has been reported as
0.0005 mg/kg body weight. (ADI: acceptable daily intake is an estimate of the amount of
a pesticide, expressed on a body weight basis, which can be ingested daily over a lifetime
without appreciable health risk.)
Fire Hazard
(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Container may explode in heat of fire. Heat above 320F may cause decomposition and evolution of highly toxic fumes of phosphorus oxides and chlorides. Hydrolyzes in alkali. Stable in neutral and acid media. Hydrolyzes in alkali.
Potential Exposure
This material is used as an insecticide on citrus, cotton, and deciduous fruit and nuts. It is also an acaricide.
Environmental Fate
Chemical/Physical. Emits toxic fumes of chlorine, phosphorus and nitrogen oxides
when heated to decomposition (Sax and Lewis, 1987)
Metabolic pathway
The metabolism of phosphamidon has been reviewed by Geissbuhler et al.
(1971) and Beynon et al. (1973). Technical phosphamidon consists of two
stereochemical isomers in the E:Z ratio of ca. 3:7. The Z-isomer has the
greater insecticidal activity.
Metabolism
The major routes of degradation are oxidative
dealkylation of the amide group and hydrolysis of the vinyl
phosphate ester bond. Dechlorination also occurs. In soils,
DT50 is 7–25 d depending upon the soil type.
Shipping
UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Toxicity evaluation
The
acute oral LD50 for rats is 17.9–30 mg/kg. Inhalation LC50
(4 h) for rats is about 0.18 mg/L air. NOEL (2 yr) for rats is
1.25 mg/kg b.w. daily. ADI is 0.5 μg/kg b.w. Phosphamidon
administered in animals is rapidly metabolized, and
85–90% of the dose is excreted within 24 h almost all in
the urine.
Degradation
Phosphamidon is rapidly hydrolysed by alkali (PM) but it is relatively
stable at neutral and acidic pH values. In alkaline solution, the compound
is hydrolysed to N,N-diethyl-2-chloroacetoacetamide (2) and
dimethyl phosphate (3) (Anliker and Beringer, 1971). There was apparently
no attack on the P-O-Me bond to give the desmethyl compound. In
acidic solution compound 2 was hydrolysed to give chloroacetone (4),
diethylamine (5) and C02. In alkaline solution 2 was dechlorinated and
hydrolysed to acetone (6), acetic acid (7) and glycolic acid diethylamide
(8). These pathways are shown in Scheme 1.
Incompatibilities
Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Strong oxidizers may cause release of toxic phosphorus oxides. Organophosphates, in the presence of strong reducing agents such as hydrides, may form highly toxic and flammable phosphine gas. Keep away from alkaline materials. Attacks metals, such as aluminum, iron, tin.
Waste Disposal
Small quantities may be treated with alkali followed by landfill disposal. Large quantities should be incinerated with effluent gas scrubbing. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
Check Digit Verification of cas no
The CAS Registry Mumber 13171-21-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,7 and 1 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 13171-21:
(7*1)+(6*3)+(5*1)+(4*7)+(3*1)+(2*2)+(1*1)=66
66 % 10 = 6
So 13171-21-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H19ClNO5P/c1-6-12(7-2)10(13)9(11)8(3)17-18(14,15-4)16-5/h6-7H2,1-5H3/b9-8+
