131775-86-5

Basic information

• Product Name: (all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester
• Synonyms: (all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester;(6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester;Heneicosapentaenoic Acid ethyl ester
• CAS NO: 131775-86-5
• Molecular Formula: C23H36O2
• Molecular Weight: 345
• Product Categories: Fatty Acid Derivatives & Lipids;Glycerols;Glycerols, Fatty Acid Derivatives & Lipids
• Mol File: 131775-86-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 431.0±34.0 °C(Predicted)
• Appearance: /
• Density: 0.907±0.06 g/cm3(Predicted)
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• Stability: Light and Temperature Sensitive
• CAS DataBase Reference: (all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: (all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester(131775-86-5)
• EPA Substance Registry System: (all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester(131775-86-5)

Safety Data

• Hazardous Substances Data: 131775-86-5(Hazardous Substances Data)

Usage

Description

(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester, also known as Heneicosapentaenoic Acid (HPA), is a 21:5 ω-3 fatty acid ester derived from marine oils. It is present in trace amounts in green algae and fish oils, with a chemical composition similar to eicosapentaenoic acid (EPA) but elongated with an additional carbon on the carboxyl end. This unique structure places the first double bond in the Δ6 position, allowing HPA to incorporate efficiently into phospholipids and triacylglycerol in vivo, similar to EPA and docosahexaenoic acid (DHA). It also exhibits strong inhibition of arachidonic acid synthesis from linoleic acid. Heneicosapentaenoic acid ethyl ester is a more lipophilic and stabilized form of the free acid, presenting as a yellow oil.

Uses

Used in Pharmaceutical Industry:
(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester is used as a therapeutic agent for the prophylaxis and treatment of various cardiovascular diseases, including hypertension, hypertriglyceridemia, and hypercholesterolemia. Its beneficial effects are attributed to its ability to incorporate into cellular lipids and modulate the synthesis of arachidonic acid, which plays a crucial role in the pathophysiology of these conditions.
Used in Nutritional Supplements:
(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester is used as a nutritional supplement to support heart health and maintain normal blood lipid levels. Its incorporation into cellular lipids and strong inhibition of arachidonic acid synthesis contribute to its potential health benefits, making it a valuable addition to dietary supplements for individuals seeking to improve their cardiovascular health.
Used in Research Applications:
(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Ethyl Ester is used as a research tool to study the significance of the position of double bonds in n-3 fatty acids. Its unique structure allows scientists to investigate the effects of fatty acid composition on cellular processes and the potential therapeutic applications of these compounds in various diseases, including cardiovascular and inflammatory conditions.