131779-46-9 Usage
Description
1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE, also known as 4-(1,2-Benzisothiazol-3-yl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester, is an organic compound that serves as a crucial intermediate in the synthesis of pharmaceutical compounds. It is characterized by its chemical structure, which includes a benzisothiazole ring and a piperazine carboxyl group, making it a valuable component in the development of various drugs.
Uses
Used in Pharmaceutical Industry:
1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE is used as an intermediate in the synthesis of Ziprasidone (Z485010) related compounds for the treatment of various psychiatric disorders. Its role in the synthesis process is essential, as it contributes to the development of medications that can help manage and alleviate symptoms associated with these conditions.
As an intermediate, 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE plays a significant role in the pharmaceutical industry, particularly in the development of antipsychotic drugs. Its unique chemical structure allows for the creation of compounds with specific therapeutic properties, making it a valuable asset in the ongoing quest to develop new and effective medications for various psychiatric disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 131779-46-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,7,7 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 131779-46:
(8*1)+(7*3)+(6*1)+(5*7)+(4*7)+(3*9)+(2*4)+(1*6)=139
139 % 10 = 9
So 131779-46-9 is a valid CAS Registry Number.
131779-46-9Relevant articles and documents
An Aryne-Based Route to Substituted Benzoisothiazoles
Chen, Yiding,Willis, Michael C.
, p. 4786 - 4789 (2015/10/12)
The combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadiazole, is possible, with the target heterocycles being obtained in good to excellent yields. In all cases, use of 3-hydroxy-4-aminothiadiazoles leads to incorporation of the amino-substituent in the product heterocycle.
Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
-
, (2008/06/13)
Various metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione which are particularly useful in the treatment of psychotic disorders, especially derivatives thereof which have been ox
