131828-51-8

Basic information

• Product Name: (3S,Z)-4-acetyl-6-<1-(benzyloxycarbonyl)indol-3-ylmethylene>-3-(2-methylpropyl)piperazine-2,5-dione
• Synonyms: (3S,Z)-4-acetyl-6-<1-(benzyloxycarbonyl)indol-3-ylmethylene>-3-(2-methylpropyl)piperazine-2,5-dione
• CAS NO: 131828-51-8
• Molecular Weight: 473.528
• Mol File: 131828-51-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S,Z)-4-acetyl-6-<1-(benzyloxycarbonyl)indol-3-ylmethylene>-3-(2-methylpropyl)piperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,Z)-4-acetyl-6-<1-(benzyloxycarbonyl)indol-3-ylmethylene>-3-(2-methylpropyl)piperazine-2,5-dione(131828-51-8)
• EPA Substance Registry System: (3S,Z)-4-acetyl-6-<1-(benzyloxycarbonyl)indol-3-ylmethylene>-3-(2-methylpropyl)piperazine-2,5-dione(131828-51-8)

Safety Data

• Hazardous Substances Data: 131828-51-8(Hazardous Substances Data)

Upstream product

• 5815-67-8 cyclo(glycyl-L-leucyl) 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 74639-50-2 N-benzyloxycarbonyl-indole-3-carbaldehyde 
• 75525-22-3 (3S)-1,4-diacetyl-3-(2-methylpropyl)piperazine-2,5-dione 

Downstream Products

• 131827-96-8 2-acetoxy-6-<1-(benzyloxycarbonyl)indol-3-ylmethyl>-5-methoxy-3-(2-methylpropyl)pyrazine 
• 131826-74-9 6-<1-(benzyloxycarbonyl)indol-3-ylmethyl>-5-methoxy-3-(2-methylpropyl)pyrazin-2(1H)-one 
• 131826-72-7 (3S,Z)-6-<1-(benzyloxycarbonyl)indol-3-ylmethylene>-5-methoxy-3-(2-methylpropyl)-3,6-dihydropyrazin-2(1H)-one 
• 131826-71-6 (3S,Z)-6-<1-(benzyloxycarbonyl)indol-3-ylmethylene>-3-(2-methylpropyl)piperazine-2,5-dione 

Relevant articles and documents

Synthesis of 2,5-Dioxygenated Pyrazine 4-Oxides: Total Synthesis of a New Inhibitor of Superoxide Anion Generation, OPC-15161

The total synthesis of OPC-15161 1, a new inhibitor of superoxide anion generation, is described in full.Three approaches, routes A-C, have been investigated focusing on the pivotal structure 2,5-dioxygenated pyrazine 4-oxide.Among them, route A led to the total synthesis of 1.That is, the key precursor, 5-hydroxypyrazin-2(1H)-one 4-oxide 7 has been prepared from tryptophan methyl ester 2 in three steps, and direct methylation of the 5-hydroxy group of 7 or three-step methylation via the 2-O-Boc derivative 10 afforded 1 in 9.9-10.6percent overall yields.