131833-90-4 Usage
Description
Bis[(4S)-(1-methylethyl)oxazolin-2-yl]methane, also known as Bis[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]methane, is a chiral ligand used in the synthesis of various organic compounds. It is characterized by its oxazoline rings and a central methane group, which provide unique structural and functional properties.
Uses
Used in Chemical Synthesis:
Bis[(4S)-(1-methylethyl)oxazolin-2-yl]methane is used as a reagent in the preparation of ditopic bisoxazoline-based chiral ligands for Henry reaction. Its chiral structure allows for the selective formation of specific enantiomers, which are important in the synthesis of pharmaceuticals and other chiral compounds.
Used in Photocatalysis:
Bis[(4S)-(1-methylethyl)oxazolin-2-yl]methane is also used in the synthesis of chiral α-hydroxy-β-ketoesters as bifunctional photocatalysts. These photocatalysts can be employed in various organic reactions, such as asymmetric catalysis and energy transfer processes, to improve reaction efficiency and selectivity.
Used in Pharmaceutical Industry:
Due to its chiral properties, Bis[(4S)-(1-methylethyl)oxazolin-2-yl]methane can be used in the development of enantioselective catalysts for the synthesis of pharmaceutical compounds. This can lead to the production of more effective and safer drugs with fewer side effects.
Used in Research and Development:
Bis[(4S)-(1-methylethyl)oxazolin-2-yl]methane can be utilized in academic and industrial research settings to explore new synthetic routes, develop novel chiral ligands, and investigate the properties of chiral compounds. This can contribute to advancements in organic chemistry and the discovery of new applications for chiral molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 131833-90-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,8,3 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 131833-90:
(8*1)+(7*3)+(6*1)+(5*8)+(4*3)+(3*3)+(2*9)+(1*0)=114
114 % 10 = 4
So 131833-90-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H22N2O2/c1-8(2)10-6-16-12(14-10)5-13-15-11(7-17-13)9(3)4/h8-11H,5-7H2,1-4H3/t10-,11-/m1/s1
131833-90-4Relevant articles and documents
Iron-catalysed enantioconvergent Suzuki-Miyaura cross-coupling to afford enantioenriched 1,1-diarylalkanes
Tyrol, Chet C.,Yone, Nang S.,Gallin, Connor F.,Byers, Jeffery A.
supporting information, p. 14661 - 14664 (2020/12/02)
The first stereoconvergent Suzuki-Miyaura cross-coupling reaction was developed to afford enantioenriched 1,1-diarylalkanes. An iron-based complex containing a chiral cyanobis(oxazoline) ligand framework was best to obtain enantioenriched 1,1-diarylalkanes from cross-coupling reactions between unactivated aryl boronic esters and benzylic chlorides. Enhanced yields were obtained when 1,3,5-trimethoxybenzene was used as an additive, which is hypothesized to extend the lifetime of the iron-based catalyst. Exceptional enantioselectivities were obtained with challenging ortho-substituted benzylic chlorides. This journal is
C2-Symmetric 4,4',5,5'-Tetrahydrobi(oxazoles) and 4,4',5,5'-Tetrahydro-2,2'-methylenebis as Chiral Ligands for Enantioselective Catalysis
Mueller, Dieter,Umbricht, Gisela,Weber, Beat,Pfaltz, Andreas
, p. 232 - 240 (2007/10/02)
The synthesis of a series of enantiomerically pure, C2-symmetric 4,4',5,5'-tetrahydro-2,2'-methylene-bis and 4,4',5,5'-tetrahydro-2,2'-bi(oxazoles) is reported.Copper complexes with anionic tetrahydromethylenebis ligands are efficient c
