131848-97-0 Usage
General Description
RO-31-8425 is a potent and selective inhibitor of the enzyme phosphodiesterase 4 (PDE4), which plays a key role in signal transduction pathways in the body. By inhibiting PDE4, RO-31-8425 increases the levels of cyclic adenosine monophosphate (cAMP) in cells, leading to a variety of downstream effects including anti-inflammatory and bronchodilatory effects. This makes RO-31-8425 a potential candidate for the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Additionally, RO-31-8425 has also shown potential for the treatment of other conditions such as depression, psoriasis, and neurodegenerative diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 131848-97-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,8,4 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 131848-97:
(8*1)+(7*3)+(6*1)+(5*8)+(4*4)+(3*8)+(2*9)+(1*7)=140
140 % 10 = 0
So 131848-97-0 is a valid CAS Registry Number.
InChI:InChI=1/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
131848-97-0Relevant articles and documents
Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction
Bit,Davis,Elliott,Harris,Hill,Keech,Kumar,Lawton,Maw,Nixon,Vesey,Wadsworth,Wilkinson
, p. 21 - 29 (2007/10/02)
The protein kinase inhibitor staurosporine has been used to design a series of selective bisindolylmaleimide inhibitors of protein kinase C (PKC). Guided by molecular graphics, conformational restriction of the cationic side chain has led to ATP competiti
