131853-06-0Relevant articles and documents
Synthesis of oxime nerve agent antidotes
-
Page/Page column 6; 7, (2020/05/16)
The present invention relates to a new route to bis-quaternary pyridinium oximes which can be utilized to restore activity of acetylcholinesterase inhibited by combination with organophosphates.
A New Class of Acyclic Phosphonate Nucleotide Analogues: Phosphonate Isosteres of Acyclovir and Ganciclovir Monophosphates as Antiviral Agents
Kim, Choung Un,Misco, Peter F.,Luh, Bing Yu,Hitchcock, Michael J. M.,Ghazzouli, Ismail,Martin, John C.
, p. 2286 - 2294 (2007/10/02)
Novel pohosphonate isosteres of acyclovir (ACV) and ganciclovir (DHPG) monophosphates (20 and 32) wre foudnd to be potent and selective antiherpesvirus agents.In the series of phosphonate analogues of ACV monophosphate, only the guanine analogue 20 exhibited activity against herpesviruses, similar to the structure-activity relationship observed for base modification of ACV analogues.The phosphonate isostere of ACV monophosphate (20) was more effective than ACV in the HSV-1 infected mouse model.The 3'-carba analogues of 9-purines/pyrimidines (adenine, HPMPA; guanine, HPMPG; cytosine, HPMPC) are devoid of antiherpesvirus activity.This result confirms that the β-oxygen atom of the phosphonomethyl ether functionality in HPMP-purines/pyrimidines plays a critical role for activity against herpesviruses.
