131880-76-7

Basic information

• Product Name: 1-(2,3-dihydro-2-Methyl-1H-indol-1-yl)-Ethanone
• Synonyms: 1-(2,3-dihydro-2-Methyl-1H-indol-1-yl)-Ethanone
• CAS NO: 131880-76-7
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Mol File: 131880-76-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2,3-dihydro-2-Methyl-1H-indol-1-yl)-Ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-dihydro-2-Methyl-1H-indol-1-yl)-Ethanone(131880-76-7)
• EPA Substance Registry System: 1-(2,3-dihydro-2-Methyl-1H-indol-1-yl)-Ethanone(131880-76-7)

Safety Data

• Hazardous Substances Data: 131880-76-7(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 6872-06-6 2-methyl indoline 
• 75-36-5 acetyl chloride 
• 68267-69-6 N-acetyl-2-allylaniline 
• 32704-22-6 2-allyl-phenylamine 
• 95-20-5 2-methyl-1H-indole 
• 103-79-7 1-phenyl-acetone 

Downstream Products

• 186792-92-7 N-acetyl-5-hydroxy-2-methylindoline 
• 841275-78-3 1-acetyl-2-methylindoline-5-sulfonyl chloride 
• 185501-27-3 4-(1-Benzyl-2-methyl-1H-indol-5-yl)-4-oxo-butyric acid ethyl ester 
• 1025883-52-6 4-(1-Benzyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-4-oxo-butyric acid ethyl ester 
• 185501-29-5 4-(1-Benzyl-3-carbamoylmethyl-2-methyl-1H-indol-5-yl)-butyric acid ethyl ester 
• 185501-28-4 4-(3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-5-yl)-4-oxo-butyric acid ethyl ester 
• 1025883-97-9 4-(1-Benzyl-3-chlorooxalyl-2-methyl-1H-indol-5-yl)-4-oxo-butyric acid ethyl ester 
• 99859-71-9 2-chloro-1-(2-methyl-indolin-5-yl)-ethanone 
• 115210-54-3 2-methyl-5-nitroindoline 
• 950589-80-7 1-(2-methyl-7-phenylindolin-1-yl)ethanone 
• 1222550-62-0 1-(2-methyl-5-((4-(4-nitrophenyl)piperazin-1-yl)sulfonyl)indolin-1-yl)ethanone 
• 901036-71-3 1-(2-methyl-5-((4-phenylpiperazin-1-yl)sulfonyl)indolin-1-yl)ethanone 
• 893152-22-2 1-(5-((4-(4-methoxyphenyl)piperazin-1-yl)sulfonyl)-2-methylindolin-1-yl)ethanone 

Relevant articles and documents

Rhodium-catalyzed direct C7 alkynylation of indolines

An efficient rhodium(III)-catalyzed direct C7 alkynylation of indoline C-H bonds with the alkynylated hypervalent iodine reagents has been developed. This reaction proceeds smoothly under mild conditions over a wide structural scope with high site-selectivity and excellent functional-group tolerance. N-Acetyl as well as other N-acyls served as effective directing groups (DG). This procedure allows for the synthesis of a variety of 7-alkynyl-substituted indolines in good to excellent yield. More significantly, C7-alkynylated indoles through further transformations have been successfully accessed.

Iridium(I)-catalyzed direct C-H bond alkylation of the C-7 position of indolines with alkenes

A cationic iridium-catalyzed C-7 alkylation of N-substituted indoline derivatives with various alkenes has been developed. A variety of 7-alkylindolines were obtained in moderate to high yields. This protocol relies on the use of the carbonyl group on the nitrogen atom of indoline as a directing group and it is potentially applicable to the large-scale synthesis of 7-alkylindoles.

Sulfonamides for the Modulation of PKM2

The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.