131885-46-6

Basic information

• Product Name: 3-(1-Imidazolyl)-2-nitroaniline
• Synonyms: 3-(1-Imidazolyl)-2-nitroaniline
• CAS NO: 131885-46-6
• Molecular Weight: 204.188
• Mol File: 131885-46-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(1-Imidazolyl)-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-Imidazolyl)-2-nitroaniline(131885-46-6)
• EPA Substance Registry System: 3-(1-Imidazolyl)-2-nitroaniline(131885-46-6)

Safety Data

• Hazardous Substances Data: 131885-46-6(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 59483-54-4 3-chloro-2-nitro-aniline 
• 19088-99-4 3-chloro-2-nitrobenzoyl chloride 
• 59772-47-3 3-chloro-2-nitrobenzamide 
• 4771-47-5 3-chloro-2-nitro-benzoic acid 

Downstream Products

• 131885-94-4 3-Imidazol-1-yl-benzene-1,2-diamine 

Relevant articles and documents

C-6 RING-SUBSTITUTED PYRIDO[1,2-a]BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS

A C-6 ring-substituted pyrido[1,2-a]benzimidazole derivative of the formula:methods of preparation and pharmaceutical compositions containing a substituted pyrido[1,2-a]benzimidzole derivative as the active ingredient are disclosed. The substituted pyrido[1,2-a]benzimidazole derivatives are useful in the treatment of central nervous system disorders.

Cardiotonic Agents. Synthesis and Cardiovascular Properties of Novel 2-Arylbenzimidazoles and Azabenzimidazoles

Novel 2-arylbenzimidazoles and azabenzimidazoles were synthesized, and their inotropic action was evaluated.Changes in left ventricular pressure, dP/dt max, were measured as an index of cardiac contractility.The structural features that impart optimal inotropic activity are presented.The most potent compounds were evaluated orally in conscious dogs with implanted Konigsberg pressure transducers.To investigate the mechanism of action, the most potent compounds were tested for their calcium-sensitizing properties and their potential for the inhibition of phosphodiesterase.Two compounds, 1 and 41, showed interesting in vitro and oral activity without side effects.They have a more potent calcium-sensitizing effect than MCI-154 and are under further investigation.