1319255-87-2

Basic information

• Product Name: 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)propan-2-ol
• Synonyms: 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)propan-2-ol;EOS-60707;2-(1-HYDROXY-1-METHYLETHYL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER
• CAS NO: 1319255-87-2
• Molecular Formula: C₁₃H₂₁BN₂O₃
• Molecular Weight: 264.12844
• Mol File: 1319255-87-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 370.0±22.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• PKA: 13.80±0.29(Predicted)
• CAS DataBase Reference: 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)propan-2-ol(1319255-87-2)
• EPA Substance Registry System: 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)propan-2-ol(1319255-87-2)

Safety Data

• Hazardous Substances Data: 1319255-87-2(Hazardous Substances Data)

Usage

Description

2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)propan-2-ol is a complex organic compound characterized by its unique molecular structure. It is a synthetic intermediate that plays a crucial role in the development of pharmaceuticals and other chemical applications due to its versatile reactivity and functional groups.

Uses

Used in Pharmaceutical Industry:
2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)propan-2-ol is used as a reactant for the preparation of aminobenzimidazole urea, which serves as an antibacterial agent. Its incorporation into the synthesis process is essential for creating compounds with potent antimicrobial properties, contributing to the development of new treatments for bacterial infections.

Upstream product

• 1193244-89-1 5-bromo-2-(1-hydroxy-1-methylethyl)pyrimidine 
• 73183-34-3 bis(pinacol)diborane 
• 89581-38-4 5-bromopyrimidine-2-carboxylic acid methyl ester 
• 1197193-30-8 ethyl 5-bromopyrimidine-2-carboxylate 

Downstream Products

• 1384984-28-4 2-[5-(4-amino-2-fluoro-5-nitro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol 
• 1384979-51-4 2-[5-(4-amino-3-nitro-5-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol 
• 1384984-18-2 (+)-(R)-1-ethyl-3-(6-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-2-yl)urea 
• 1384984-29-5 2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol 
• 1384979-52-5 2-[5-(3,4-diamino-5-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol 

Relevant articles and documents

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors

A series of dual-targeting, alcohol-containing benzothiazoles has been identified with superior antibacterial activity and drug-like properties. Early lead benzothiazoles containing carboxylic acid moieties showed efficacy in a well-established in vivo model, but inferior drug-like properties demanded modifications of functionality capable of demonstrating superior efficacy. Eliminating the acid group in favor of hydrophilic alcohol moieties at C 5, as well as incorporating solubilizing groups at the C7 position of the core ring provided potent, broad-spectrum Gram-positive antibacterial activity, lower protein binding, and markedly improved efficacy in vivo.