1319719-22-6Relevant articles and documents
Synthesis and biological evaluation of orally active hypolipidemic agents
Bandgar, Babasaheb P.,Sarangdhar, Rajendra J.,Khan, Fruthous,Mookkan, Jeyamurugan,Shetty, Pranesha,Singh, Gajendra
experimental part, p. 5915 - 5926 (2011/10/08)
A series of novel fenofibric acid ester prodrugs 1c-1h were synthesized and evaluated with the aim of obtaining potent hypolipidemic agents. Prodrugs 1c and 1d exhibited potent hypochlolesterolemic activity, lowering the mice plasma triglyceride level up to 47% in Swiss albino mice after oral administration of 50 mg/kg/day for 8 days. Fenofibric acid ester prodrugs 1c-1h were found lipophilic like fenofibrate (1b), indicated by partition coefficients measured in octanol-buffer system at pH 7.4. On the basis of in vivo studies, prodrugs 1c and 1d emerged as potent hypolipidemic agents.
