1319726-69-6

Basic information

• Product Name: C₂₃H₂₈N₂O₃S₂
• CAS NO: 1319726-69-6
• Molecular Weight: 444.619
• Mol File: 1319726-69-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₈N₂O₃S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₈N₂O₃S₂(1319726-69-6)
• EPA Substance Registry System: C₂₃H₂₈N₂O₃S₂(1319726-69-6)

Safety Data

• Hazardous Substances Data: 1319726-69-6(Hazardous Substances Data)

Upstream product

• 50562-79-3 1-(4-tolylsulfonyl)indole-3-carboxaldehyde 
• 106-95-6 allyl bromide 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Downstream Products

• 639-43-0 (-)-akuammicine 
• 38681-90-2 echitamidine 
• 639-43-0 akuammicine 

Relevant articles and documents

Asymmetric total synthesis of (?)-melotenine A

We have developed a sequential one-pot Mitsunobu/intramolecular aza-Baylis–Hillman reaction to construct the ABCE tetracyclic core of the Strychnos alkaloids and applied this method to the total synthesis of (?)-melotenine A (1), a novel rearranged Aspidosperma alkaloid with potent cytotoxic activity. Additional key steps in the synthesis included (1) a Piers annulation of a vinyl iodide and a methyl ketone to prepare the D ring and (2) a site-selective intermolecular vinylogous aldol reaction to functionalize the E ring.

Total synthesis of (-)-melotenine A

'Melo' out: A concise asymmetric synthesis of (-)-melotenine A has been accomplished in fourteen steps and 1 % overall yield from commercial N-tosylindole-3-carboxaldehyde. Key steps include a Piers annulation, an intermolecular vinylogous aldol reaction, and a novel one-pot sequence to prepare the ABCE tetracycle. Boc=tert-butoxycarbonyl, Ts=4-toluenesulfonyl. Copyright