13199-25-2Relevant articles and documents
Thioimidate N-oxides: From nature to synthetic pathways
Schleiss, Julie,Cerniauskaite, Deimante,Gueyrard, David,Iori, Renato,Rollin, Patrick,Tatibou?t, Arnaud
, p. 725 - 728 (2010)
Inspired by the unexpected reactivity of desulfated naturally occurring glucoraphenin, methods to synthesize thioimidate N-oxides (TIO) have been devised on simple or carbohydrate templates. Either through halocyclization or under Mitsunobu conditions, the starting thiohydroximates cyclized to generate efficiently the corresponding TIO. Georg Thieme Verlag Stuttgart ? New York.
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Hughes,Speakman
, p. 171,173 (1965)
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Stereoselective total synthesis of goniothalesdiol A via chiron approach
Yadav, Jhillu S.,Nageshwar Rao, Ragam,Somaiah, Ragam,Harikrishna, Valaboju,Subba Reddy, Basi V.
experimental part, p. 1362 - 1368 (2010/09/20)
The stereocontrolled synthesis of goniothalesdiol A, a dihydroxylated tetrahydropyran compound, has been accomplished using d-ribose as chiral precursor. The key steps involved are aryl Grignard reaction, stereoselective alkoxy-directed keto reduction, and intramolecular oxy-Michael addition.
Synthesis and l-fucosidase inhibitory activity of a new series of cyclic sugar imines-in situ formation and assay of their saturated counterparts
Behr, Jean-Bernard
scheme or table, p. 4498 - 4501 (2009/11/30)
The synthesis of a series of aryl-substituted cyclic sugar imines was performed via a tandem nucleophilic addition/substitution reaction. The so-obtained ketimines displayed fucosidase inhibitory activities (IC50 = 46-556 μM). Their reduced counterparts were prepared and assayed after addition of sodium borohydride to the enzymatic assay stock solution. The pyrrolidines strongly inhibit fucosidase (IC50 = 0.65-150 μM).