13200-83-4

Basic information

• Product Name: 1-formyl-L-proline
• Synonyms: 1-formyl-L-proline;L-Proline, 1-formyl- (9CI);Einecs 236-165-2;N-ForMyl-L-proline >=97% (TLC)
• CAS NO: 13200-83-4
• Molecular Formula: C₆H₉NO₃
• Molecular Weight: 143.14056
• EINECS: 236-165-2
• Product Categories: ALDEHYDE
• Mol File: 13200-83-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 93-94 °C
• Boiling Point: 375°C at 760 mmHg
• Flash Point: 180.6°C
• Appearance: /
• Density: 1.451g/cm³
• Vapor Pressure: 1.17E-06mmHg at 25°C
• Refractive Index: 1.622
• PKA: 3.66±0.20(Predicted)
• CAS DataBase Reference: 1-formyl-L-proline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-formyl-L-proline(13200-83-4)
• EPA Substance Registry System: 1-formyl-L-proline(13200-83-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 13200-83-4(Hazardous Substances Data)

Usage

General Description

1-formyl-L-proline is a chemical compound that belongs to the class of organic compounds known as proline and derivatives. It is a derivative of the amino acid proline, characterized by the presence of a formyl group at the first position on the carbon chain. 1-formyl-L-proline is used in biochemical research and pharmaceutical development. It has potential applications as a diagnostic reagent for detecting certain amino acids and as a building block in the synthesis of peptides and other organic compounds. 1-formyl-L-proline may also have potential biological activities and may be studied for its potential therapeutic uses in the future.

InChI:InChI=1/C6H9NO3/c8-4-7-3-1-2-5(7)6(9)10/h4-5H,1-3H2,(H,9,10)

Upstream product

• 64-18-6 formic acid 
• 147-85-3 L-proline 
• 75-87-6 chloral 
• 77287-34-4 formamide 

Downstream Products

• 129398-84-1 (S)-methyl 2-((S)-1-formylpyrrolidine-2-carbonylamino)-3-phenylpropanoate 
• 62563-06-8 dimethyl 2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate 
• 34381-71-0 (S)-2-hydroxymethyl-1-methylpyrrolidine 
• 67824-38-8 (S)-(-)-1-methyl-2-chloromethylpyrrolidine hydrochloride 
• 74259-08-8 1-((S)-3-mercapto-2-methylpropanoyl)-L-prolyl-L-phenylalanine 
• 74258-86-9 alacepril 
• 13589-02-1 L-prolyl-L-phenylalanine 
• 1166392-78-4 (2S)-N-[(4S,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-1-formylpyrrolidine-2-carboxamide 
• 1166392-75-1 (2S)-1-formyl-N-[(R)-1-(2-naphthyl)ethyl]pyrrolidine-2-carboxamide 
• 1166392-76-2 benzyl (2S)-2-{[(2S)-1-formylpyrrolidin-2-ylcarbonyl]amino}-3-methylbutanoate 

Relevant articles and documents

New tricyclic heterocycles. Synthesis of derivatives of 2-azapyrrolo[1,2-a]indole

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Synthesis of mono-and diphosphorus-substituted proline derivatives containing P–C–N fragments

Convenient methods for the synthesis of new types of mono-and diphosphorus-substituted proline derivatives containing P–C–N fragments were developed based on special pre-prepared proline-containing synthons. The corresponding organophosphorus acids including a proline fragment were also synthesized.

A convenient procedure for N-formylation of amines

A simple and convenient method for the N-formylation of primary and secondary amines including amino acids has been developed utilizing formamide and sodium methoxide in moderate to excellent yield. This reagent is also utilized for one pot conversion of compounds having amino esters to N-formyl amides.

Asymmetric transfer hydrogenation of ketimines with trichlorosilane: Structural studies

We report structural and mechanistic studies on the organocatalytic asymmetric transfer hydrogenation of ketimines with trichlorosilane. Amines were obtained in good yields and moderate enantioselectivities. Both experiment and computation were utilized to provide an improved understanding of the mechanism. Georg Thieme Verlag Stuttgart.