1320211-23-1

Basic information

• Product Name: C₃₃H₃₆ClNO₄S
• CAS NO: 1320211-23-1
• Molecular Weight: 578.172
• Mol File: 1320211-23-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₃₆ClNO₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₃₆ClNO₄S(1320211-23-1)
• EPA Substance Registry System: C₃₃H₃₆ClNO₄S(1320211-23-1)

Safety Data

• Hazardous Substances Data: 1320211-23-1(Hazardous Substances Data)

Upstream product

• 24824-93-9 chloromethyl p-tolyl sulfoxide 
• 94226-56-9 tert-butyl 2-(dibenzylamino)ethanoate 
• 98-01-1 furfural 

Relevant articles and documents

Multisubstituted α,β-unsaturated γ-lactones from 1-chlorovinyl p-tolyl sulfoxides and tert-butyl carboxylates using Pummerer-type cyclization as the key reaction

The addition reaction of 1-chlorovinyl p-tolyl sulfoxides, derived from aldehydes and chloromethyl p-tolyl sulfoxide, with the lithium enolate of tert-butyl carboxylates gave adducts in quantitative yields. Treatment of the adducts with trifluoroacetic anhydride in the presence of sodium iodide resulted in the formation of γ-lactones bearing a p-tolylsulfanyl group at the γ-position through Pummerer-type cyclization. Oxidation of the sulfanyl group to the sulfinyl group followed by thermal syn-elimination gave α,β-unsaturated γ-lactones (γ-butenolides) in moderate to good yields. Trapping the intermediates of the addition reaction with iodoalkanes gave alkylated adducts, from which α,γ;- and β,γ-disubstituted γ-butenolides were obtained. These procedures provide a good way to synthesize multisubstituted γ-butenolides from aldehydes. Georg Thieme Verlag Stuttgart New York.