1320256-66-3

Basic information

• Product Name: (E)-N-(tert-butyl)-4-(3-fluorophenyl)-2-oxobut-3-enamide
• Synonyms: (E)-N-(tert-butyl)-4-(3-fluorophenyl)-2-oxobut-3-enamide
• CAS NO: 1320256-66-3
• Molecular Weight: 249.285
• Mol File: 1320256-66-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-N-(tert-butyl)-4-(3-fluorophenyl)-2-oxobut-3-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(tert-butyl)-4-(3-fluorophenyl)-2-oxobut-3-enamide(1320256-66-3)
• EPA Substance Registry System: (E)-N-(tert-butyl)-4-(3-fluorophenyl)-2-oxobut-3-enamide(1320256-66-3)

Safety Data

• Hazardous Substances Data: 1320256-66-3(Hazardous Substances Data)

Upstream product

• 456-48-4 3-Fluorobenzaldehyde 
• 75-64-9 tert-butylamine 
• 119072-55-8 tert-butylisonitrile 
• 42291-83-8 (E)-3-(3-fluorophenyl)acrylaldehyde 
• 1320257-23-5 C₁₄H₁₈FNO₂ 
• 56578-38-2 3-fluorocinnamaldehyde 

Downstream Products

• 1637759-14-8 N-tert-butyl-4-(3-fluorophenyl)-2-oxo-4-phenylbutanamide 
• 1637758-67-8 (R)-N-tert-butyl-4-(3-fluorophenyl)-2-oxo-4-phenylbutanamide 

Relevant articles and documents

Iridium/f-Amphox-Catalyzed Asymmetric Hydrogenation of Styrylglyoxylamides

We report an iridium-catalyzed asymmetric hydrogenation reaction for the preparation of chiral homophenylalanine derivatives. Catalyzed by an iridium/f-amphox complex, the asymmetric hydrogenation of styrylglyoxylamides was conducted smoothly with turnover numbers of up to 10,000 and up to 98% ee. This method was successfully applied in a synthesis of a fragment of benazepril, a drug used for the treatment of high blood pressure.

Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

The development of small molecule inhibitors of the viral protease is of considerable interest for the treatment of emergent flaviviral diseases such as Dengue or West Nile fever. Until today little progress has been made in finding drug-like compounds th