1320361-74-7Relevant articles and documents
6-bromo-4-chloroquinoline preparation method
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Paragraph 0022; 0023; 0032; 0033; 0041; 0042, (2017/03/28)
The invention discloses a 6-bromo-4-chloroquinoline preparation method. 4-bromaniline, ethyl propiolate, phosphorus trichloride and the like are used as raw materials to obtain a target product 6-bromo-4-chloroquinoline through three-step reaction. The 6-bromo-4-chloroquinoline preparation method is convenient and simple in operation and environment friendly, the comprehensive yield is 70% or above and remarkably increased as compared with existing yield which is 26-42%, existing medicine production cost is sharply reduced, and the 6-bromo-4-chloroquinoline preparation method is suitable for industrial mass production.
Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions
Mugnaini, Claudia,Falciani, Chiara,De Rosa, Maria,Brizzi, Antonella,Pasquini, Serena,Corelli, Federico
supporting information; experimental part, p. 5776 - 5783 (2011/08/21)
A practical and general synthesis of 1,3,6-trisubstituted quinolin-4(1H)-ones starting from 1-alkyl-6-bromo-3-iodoquinolin-4(1H)-one is described, based on regioselective sequential palladium-catalyzed cross-coupling reactions, namely Suzuki-Miyaura, Sono