132111-54-7

Basic information

• Product Name: Methanone, (5,6-dihydro-4H-imidazo[1,2-c][1,2,3]triazol-3-yl)(4-methoxyphenyl)-
• CAS NO: 132111-54-7
• Molecular Formula: C12H12N4O2
• Molecular Weight: 244.253
• Mol File: 132111-54-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanone, (5,6-dihydro-4H-imidazo[1,2-c][1,2,3]triazol-3-yl)(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (5,6-dihydro-4H-imidazo[1,2-c][1,2,3]triazol-3-yl)(4-methoxyphenyl)-(132111-54-7)
• EPA Substance Registry System: Methanone, (5,6-dihydro-4H-imidazo[1,2-c][1,2,3]triazol-3-yl)(4-methoxyphenyl)-(132111-54-7)

Safety Data

• Hazardous Substances Data: 132111-54-7(Hazardous Substances Data)

Upstream product

• 107195-10-8 2-(imidazolidin-2-ylidene)-1-(4-methoxyphenyl)ethan-1-one 
• 2377-81-3 tetrafluoroisophthalonitrile 
• 1897-45-6 chlorothalonil 
• 1897-50-3 5-chloro-2,4,6-trifluoroisophthalonitrile 
• 622-37-7 Phenyl azide 

Relevant articles and documents

Transition-Metal-Free Annulation of Enamines and Tosyl Azide toward N-Heterocycle Fused and 5-Amino-1,2,3-Triazoles

The annulation reactions between gem-diamino enaminones (ketene aminals) and tosyl azide providing N-heterocycle fused and 5-amino side chain functionalized 1,2,3-triazoles have been developed. The synthesis of these N-side chain functionalized 1,2,3-tria

An efficient one-pot synthesis of heterocycle-fused 1,2,3-triazole derivatives as anti-cancer agents

A series of heterocycle-fused 1,2,3-triazoles were easily prepared by the 1,3-dipolar cycloaddition of heterocyclic ketene aminals or N,O-acetals with sodium azide and polyhalo isophthalonitriles in a one-pot reaction at room temperature without a catalyst and evaluated in vitro against a panel of human tumour cell lines. 1,3-Oxazoheterocycle fused 1,2,3-triazoles were more potent against the tumour cell lines Skov-3, HL-60, A431, A549 and HepG-2 than 1,3-diazoheterocycle fused 1,2,3-triazoles. 4-Methoxyphenyl substituted 1,3-oxazoheterocycle fused 1,2,3-triazole 6j was found to be the most potent derivative with IC50 values lower than 1.9 μg/mL against A431 and K562 human tumour cell lines.