1321619-38-8

Basic information

• Product Name: (Z)-3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid
• Synonyms: (Z)-3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid
• CAS NO: 1321619-38-8
• Molecular Weight: 295.056
• Mol File: 1321619-38-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (Z)-3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid(1321619-38-8)
• EPA Substance Registry System: (Z)-3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid(1321619-38-8)

Safety Data

• Hazardous Substances Data: 1321619-38-8(Hazardous Substances Data)

Upstream product

• 381-98-6 trifluoromethyacrylic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 2516-99-6 3,3,3-Trifluoropropionic acid 
• 1122-91-4 4-bromo-benzaldehyde 

Relevant articles and documents

Ligand Free Palladium-Catalyzed Synthesis of α-Trifluoromethylacrylic Acids and Related Acrylates by Three-Component Reaction

Aryl iodides and 2-(trifluoromethyl)acrylic acid reacted together in ligand-free Mizoroki-Heck reaction furnishing a quick and efficient access to highly valuable α-trifluoromethylacrylic acids. The useful transformation was independent with regard to the electronic nature of the aryl group substituent. A three-component one-pot version was also developed to give diverse substituted acrylates. The versatility of α-trifluoromethylacrylic acids was demonstrated by quick access to 3-CF3-coumarins as well as fluorinated analogues of therapeutic or cosmetic agents. Finally, we proposed a catalytic cycle based on the silver carboxylate salt, identified as a key intermediate in the reaction. (Figure presented.).

Catalytic asymmetric hydrogenation of α-CF3- or β-CF3-Substituted acrylic acids using Rhodium(I) complexes with a combination of chiral and achiral ligands

Only the mixture works! Acrylic acid derivatives with CF3 substituents in α or β position were efficiently hydrogenated in the presence of a RhI complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph3P as ligands. The corresponding propanoic acid derivatives were obtained with generally high conversion (>99 %) and high enantioselectivity (92->99 %). Copyright

Titanium-mediated direct carbon-carbon double bond formation to α-trifluoromethyl acids: A new contribution to the knoevenagel reaction and a high-yielding and stereoselective synthesis of α- trifluoromethylacrylic acids

An efficient strategy for a high-yielding and stereoselective synthesis of α-trifluoromethyl unsaturated carboxylic acids directly from the reactions of 3,3,3-trifluoropropanoic acid (CF3CH2COOH) with various aryl aldehydes in the pr