132207-04-6

Basic information

• Product Name: 1H-imidazo[4,5-c]-quinolin-4-amine
• Synonyms: 1H-imidazo[4,5-c]-quinolin-4-amine
• CAS NO: 132207-04-6
• Molecular Weight: 184.2
• Mol File: 132207-04-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-imidazo[4,5-c]-quinolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-imidazo[4,5-c]-quinolin-4-amine(132207-04-6)
• EPA Substance Registry System: 1H-imidazo[4,5-c]-quinolin-4-amine(132207-04-6)

Safety Data

• Hazardous Substances Data: 132207-04-6(Hazardous Substances Data)

Usage

Description

1H-Imidazo[4,5-c]-quinolin-4-amine is an organic compound with the chemical formula C11H10N4. It is a derivative of imidazoquinoline, a heterocyclic compound with a fused imidazole and quinoline ring system. 1H-imidazo[4,5-c]-quinolin-4-amine is known for its potential applications in the pharmaceutical industry due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
1H-Imidazo[4,5-c]-quinolin-4-amine is used as a reactant/reagent for the preparation of imidazoquinoline derivatives, which are known as immune response modifiers. These modified compounds can potentially enhance the body's immune response, making them valuable in the development of new drugs and therapies for various diseases and conditions.
Used in Research and Development:
1H-Imidazo[4,5-c]-quinolin-4-amine can also be utilized in research and development settings to study the properties and potential applications of imidazoquinoline derivatives. This may include investigating their chemical reactivity, stability, and interactions with biological systems, as well as exploring their potential use in drug discovery and development.

Upstream product

• 39061-97-7 4-chloro-3-nitroquinoline 
• 50332-66-6 3-nitro-quinolin-4-ol 
• 42606-33-7 3-nitro-4-aminoquinoline 
• 87751-33-5 quinoline-3,4-diamine 
• 132521-66-5 2,4-dichloro-3-nitroquinoline 
• 15151-57-2 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-one 
• 879000-84-7 N₄-{tert-butyl}-2-chloroquinoline-3,4-diamine 
• 132521-60-9 4-chloro-1-(1,1-dimethylethyl)-1H-imidazo[4,5-c]quinoline 
• 132521-61-0 1-(1,1-dimethylethyl)-1H-imidazo[4,5-c]quinolin-4-amine 
• 132206-92-9 4-chloro-1H-imidazo[4,5-c]-quinoline 
• 7440-44-0 pyrographite 
• 132206-91-8 1H-imidazo<4,5-c>quinolin-5-oxide 
• 233-56-7 1H-imidazo[4,5-c]quinoline 

Downstream Products

• 437602-81-8 1-[(benzyloxy)methyl]-1H-imidazo[4,5-c]quinolin-4-amine 

Relevant articles and documents

Synthesis and structure - Activity-relationships of 1H-imidazo[4,5-c] quinolines that induce interferon production

1H-Imidazo-[4,5-c]quinolines were prepared while investigating novel nucleoside analogues as potential antiviral agents. While these compounds showed no direct antiviral activity when tested in a number of cell culture systems, some demonstrated potent inhibition of virus lesion development in an intravaginal guinea pig herpes simplex virus-2 assay. We have determined that the in vivo antiviral activity can be attributed to the ability of these molecules to induce the production of cytokines, especially interferon (IFN), in this model. Subsequently, we found that the compounds also induce in vitro production of IFN in human peripheral blood mononuclear cells (hPBMCs). The in vitro results reported herein and the in vivo results reported previously led to the discovery of imiquimod, 26, which was developed as a topical agent and has been approved for the treatment of genital warts, actinic keratosis, and superficial basal cell carcinoma.

1H-Imidazoquinolin-4-amines: Novel Non-Xanthine Adenosine Antagonists

On the basis of a model we recently developed for the antagonist binding site of the adenosine A1 receptor (J.Med.Chem. 1990, 33, 1708-1713), it was predicted that 1H-imidazoquinolin-4-amines would be antagonists of the A1 rec