13221-86-8

Basic information

• Product Name: 2,4-DIHYDROXYBENZHYDRAZIDE
• Synonyms: IFLAB-BB F0777-0787;AKOS BC-1514;2,4-DIHYDROXYBENZHYDRAZIDE;2,4-DIHYDROXYBENZOHYDRAZIDE;2,4-DIHYDROXYBENZOIC ACID HYDRAZIDE;2,4-Dihydroxybenzoic hydrazide;Benzoic acid, 2,4-dihydroxy-, hydrazide
• CAS NO: 13221-86-8
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Carbonyl Compounds;Hydrazides;Organic Building Blocks
• Mol File: 13221-86-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 247-250 °C(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.477g/cm³
• Refractive Index: 1.67
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Dimethylformamide
• PKA: 8.22±0.35(Predicted)
• BRN: 2641320
• CAS DataBase Reference: 2,4-DIHYDROXYBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIHYDROXYBENZHYDRAZIDE(13221-86-8)
• EPA Substance Registry System: 2,4-DIHYDROXYBENZHYDRAZIDE(13221-86-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 13221-86-8(Hazardous Substances Data)

Usage

Uses

2,4-Dihydroxybenzoic acid hydrazide may be used in the synthesis of:2,4-dihydroxy-N′-(4-methoxybenzylidene)benzohydrazide2,4-dihydroxy-N′-(2-hydroxy-4-methoxybenzylidene)benzohydrazide(E)-2,4-dihydroxy-N′-(2-hydroxy-3-methoxy-5-nitrobenzylidene) benzohydrazide dihydrate[N′-(5-chloro-2-oxidobenzyl-κO)-2,4-dihydroxybenzohydrazidato-κ2N′,O](methanol-κO)dioxidomolybdenum(VI)–4,4′-bipyridine(E)-N′-(3,4-dimethoxybenzylidene)-2,4-dihydroxybenzohydrazide methanol solvate

General Description

2,4-Dihydroxybenzoic acid hydrazide is a phenolic hydrazide. 2,4-Dihydroxybenzohydrazide can be prepared by employing ethyl 2,4-dihydroxybenzoate and hydrazine hydrate as starting reagent.

InChI:InChI=1/C7H8N2O3/c8-9-7(12)5-2-1-4(10)3-6(5)11/h1-3,10-11H,8H2,(H,9,12)

Upstream product

• 4143-00-4 ethyl 2,4-dihydroxybenzoate 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 89-86-1 4-hydroxysalicylic acid 
• 57438-38-7 2,4-dihydroxybenzoyl chloride 

Downstream Products

• 117839-86-8 1-(2,4-dihydroxy-benzoyl)-4-(4-methoxy-phenyl)-thiosemicarbazide 
• 19949-22-5 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-oxadiazole 
• 807628-49-5 C₃₁H₃₃N₅O₇Si 
• 19949-32-7 2,4-diacetoxy-1-(5-acetylamino-[1,3,4]oxadiazol-2-yl)-benzene 
• 19949-33-8 1-(5-benzoylamino-[1,3,4]oxadiazol-2-yl)-2,4-bis-benzoyloxy-benzene 
• 891096-34-7 1-(2,4-dihydroxy-benzoyl)-4-(2-fluorophenyl)-thiosemicarbazide 
• 405225-10-7 5-chlorosalicylaldehyde 2,4-dihydroxybenzoylhydrazone 
• 405220-69-1 2,4-dihydroxy-N'-(4-methoxybenzylidene)benzohydrazide 

Relevant articles and documents

Electrochemical and spectroscopic investigations of isoniazide and its analogs with ds.DNA at physiological pH: Evaluation of biological activities

Interaction and binding of isonicotinic acid hydrazide (INH) and its two analogs; pyrazine carboxylic acid hydrazide (PCH) and 2,4-dihydroxy benzoic acid hydrazide (2,4-DHBAH) with DNA has been investigated by UV-spectroscopy and cyclic voltammetry (CV) a

Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis

Glycine-N-methyl transferase (GNMT) downregulation results in spontaneous hepatocellular carcinoma (HCC). Overexpression of GNMT inhibits the proliferation of liver cancer cell lines and prevents carcinogen-induced HCC, suggesting that GNMT induction is a potential approach for anti-HCC therapy. Herein, we used Huh7 GNMT promoter-driven screening to identify a GNMT inducer. Compound K78 was identified and validated for its induction of GNMT and inhibition of Huh7 cell growth. Subsequently, we employed structure-activity relationship analysis and found a potent GNMT inducer, K117. K117 inhibited Huh7 cell growth in vitro and xenograft in vivo. Oral administration of a dosage of K117 at 10 mpk (milligrams per kilogram) can inhibit Huh7 xenograft in a manner equivalent to the effect of sorafenib at a dosage of 25 mpk. A mechanistic study revealed that K117 is an MYC inhibitor. Ectopic expression of MYC using CMV promoter blocked K117-mediated MYC inhibition and GNMT induction. Overall, K117 is a potential lead compound for HCC- and MYC-dependent cancers.

Aromatic acyl hydrazone derivative and application thereof as NA inhibitor

The invention relates to an aromatic acyl hydrazone derivative as shown in a structural formula I, pharmaceutically acceptable salt and a pharmaceutical composition thereof, and application of the aromatic acyl hydrazone derivative and the pharmaceutically acceptable salt and the pharmaceutical composition in preparation of an influenza virus neuraminidase inhibitor, wherein R is one of trifluoromethyl, nitryl, 3-methyl-4-nitryl, 3-hydroxyl-4-nitryl, 3-nitryl-4-hydroxyl, hydroxyl, dihydroxyl, dinitryl, 3-methoxy-4-hydroxyl or trihydroxyl; Y is selected from hydroxyl, dihydroxyl, 2-hydroxyl-3-methoxy, 2-hydroxyl-4-methoxy,2-hydroxyl-5-methoxy,2-hydroxyl-6-methoxy,3-hydroxyl-2-methoxy,3-hydroxyl-4-methoxy,3-hydroxyl-5-methoxy,3-hydroxyl-6-methoxy,4-hydroxyl-2-methoxy,4-hydroxyl-3-methoxy,4-hydroxyl-3,5-dimethoxy, trihydroxyl, 4-hydroxyl-3-ethoxy, or 4-hydroxyl-3,5-dimethoxy; w is selected from CH or N; and z is selected from CH or N.