13224-63-0 Usage
General Description
22 beta-angeloyloxyoleanolic acid is a triterpenoid compound found in natural sources such as the plants of the genus Tabebuia. It possesses potential medicinal properties and has been studied for its anti-inflammatory, anti-microbial, and anti-cancer activities. The compound has shown inhibitory effects on tumor cell growth and has demonstrated anti-inflammatory effects by reducing the production of pro-inflammatory mediators. Additionally, 22 beta-angeloyloxyoleanolic acid has shown promising antimicrobial activity against various pathogens, making it a potential candidate for the development of new therapeutic agents. Overall, this compound holds potential for pharmaceutical and medicinal application due to its diverse therapeutic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 13224-63-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,2,2 and 4 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13224-63:
(7*1)+(6*3)+(5*2)+(4*2)+(3*4)+(2*6)+(1*3)=70
70 % 10 = 0
So 13224-63-0 is a valid CAS Registry Number.
InChI:InChI=1/C35H54O5/c1-10-21(2)28(37)40-27-20-30(3,4)19-23-22-11-12-25-32(7)15-14-26(36)31(5,6)24(32)13-16-34(25,9)33(22,8)17-18-35(23,27)29(38)39/h10-11,23-27,36H,12-20H2,1-9H3,(H,38,39)/b21-10+/t23-,24?,25-,26+,27-,32+,33-,34-,35+/m1/s1
13224-63-0Relevant articles and documents
Reduced Lantadenes A and B: Semi-synthetic synthesis, selective cytotoxicity, apoptosis induction and inhibition of NO, TNF-α production in HL-60 cells
Kumar, Suthar Sharad,Tailor, Navin,Lee, Hong Boon,Sharma, Manu
, p. 3379 - 3388 (2013)
The aim of this study was to investigate the effect of pentacyclic triterpenoids-reduced Lantadenes A (3) and B (4) on the cytotoxicity, stimulation of apoptosis and regulation of transcription factors in HL-60 cells. The 3 and 4 are the minor compounds of weed Lantana camara L. (Verbenaceae) and were prepared semi-synthetically in single step by reducing Lantadenes A (1) and B (2) under microwave irradiation with yield of 98-99 %. The 3 and 4 demonstrated selective cytotoxicity against HL-60, MCF-7, HSC-2, and HCT-116 cancer cell lines (IC50 1.2-6.4 μM) and were found non-toxic toward normal cells (VERO) with IC50 >50). The compounds 3 and 4 (15 μM)-induced apoptosis by activation of caspase-3 and bax, along with significant decrease in expression of NF-kB (p-65) and bcl-2 in HL-60 cells. The compounds 3 and 4 at 15 μM significantly suppressed the production of nitrite, TNF-α, and iNOS gene expression in HL-60 cells. The results suggested that reduced Lantadenes A and B have the potential to be developed as anticancer agents.
