132269-38-6 Usage
Description
5-amino-1-(4-chlorobenzyl)-1H-1,2,3-triazole-4-carboxamide is an organic compound with the molecular formula C10H9ClN4O. It is characterized by its triazole ring structure and the presence of an amino group, a chlorobenzyl group, and a carboxamide functional group. 5-amino-1-(4-chlorobenzyl)-1H-1,2,3-triazole-4-carboxamide is known for its potential applications in various industries, particularly in pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
5-amino-1-(4-chlorobenzyl)-1H-1,2,3-triazole-4-carboxamide is used as a reactant in the preparation of benzylated 1,2,3-triazoles. These benzylated triazoles are known for their pharmacological properties and are often utilized as building blocks for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 5-amino-1-(4-chlorobenzyl)-1H-1,2,3-triazole-4-carboxamide is used as a reactant for the synthesis of anticoccidiostats. Coccidiosis is a disease that affects domestic animals, particularly poultry, and is caused by protozoan parasites of the genus Eimeria. The compound plays a crucial role in the development of these anticoccidiostats, which are essential for the prevention and treatment of coccidiosis in livestock.
Check Digit Verification of cas no
The CAS Registry Mumber 132269-38-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,2,6 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 132269-38:
(8*1)+(7*3)+(6*2)+(5*2)+(4*6)+(3*9)+(2*3)+(1*8)=116
116 % 10 = 6
So 132269-38-6 is a valid CAS Registry Number.
132269-38-6Relevant articles and documents
Benzylated 1,2,3-triazoles as anticoccidiostats
Bochis,Chabala,Harris,Peterson,Barash,Beattie,Brown,Graham,Waksmunski,Tischler,Joshua,Smith,Colwell,Wyvratt Jr.,Fisher,Tamas,Nicolich,Schleim,Wilks
, p. 2843 - 2852 (2007/10/02)
Substituted 5-amino-4-carbamoyl-1,2,3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes proceeded by brominating appropriately substituted toluenes 4a-s,v to 5a-s,v. In Scheme I, the brominated benzyl analogues 5 were converted to the corresponding benzyl azides 6, which were treated with cyanoacetamide to yield 1-substituted-5-amino-4-carbamoyl-1,2,3-triazoles 3. In Scheme II, the benzyl halides 5 were employed to alkylate the sodium salt of 5-amino-4-carbamoyl-1,2,3-triazole (7). Preliminary screening data against Eimeria acervulina and E. tenella in chickens suggested structural requirements for maximizing activity. Further evaluation against a relatively resistant series of eight Eimeria field isolates revealed L-651,582 (3a) to be a highly effective coccidiostat. However, unacceptable tissue residues precluded further development. Mechanistic studies on this series of 5-amino-4-carbamoyl-1,2,3-triazoles and, in particular, on L-651,582 (3a) revealed that its mode of action does not involve inhibition of IMP dehydrogenase, but probably interferes with host cell calcium entry. In addition, L-651,582 has been found to have antiproliferative activity in several disease models and was recently reported to possess antimetastatic activity in a model of ovarian cancer progression.
