132283-68-2

Basic information

• Product Name: 2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde
• Synonyms: 2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde
• CAS NO: 132283-68-2
• Molecular Weight: 228.675
• Mol File: 132283-68-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde(132283-68-2)
• EPA Substance Registry System: 2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde(132283-68-2)

Safety Data

• Hazardous Substances Data: 132283-68-2(Hazardous Substances Data)

Upstream product

• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 1203801-41-5 C₁₁H₁₄O₄ 
• 132283-67-1 6,7-dimethoxy-1-ethoxyisochroman 

Downstream Products

• 1415385-73-7 (R)-N-{(E)-[2-(2-chloroethyl)-4,5-dimethoxyphenyl]methylidene}-2-methylpropane-2-sulfinamide 
• 1447840-64-3 (R)-N-((S)-1-(2-(2-chloroethyl)-4,5-dimethoxyphenyl)ethyl)-2-methylpropane-2-sulfinamide 
• 140367-63-1 3,4-dihydro-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)methyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester 
• 1350895-86-1 6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline 
• 871224-64-5 almorexant 
• 1609564-22-8 (S)-tert-butyl-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1609564-20-6 (S)-tert-butyl 1-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 769172-81-8 (S)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline 
• 1415385-74-8 (R)-N-((S)-1-(2-(2-chloroethyl)-4,5-dimethoxyphenyl)but-3-enyl)-2-methylpropane-2-sulfinamide 

Relevant articles and documents

Cascade condensation, cyclization, intermolecular dipolar cycloaddition by multi-component coupling and application to a synthesis of (±)-crispine A

A general approach for the synthesis of various nitrogen-containing heterocyclic compounds is described using an intermolecular dipolar cycloaddition reaction of azomethine ylides and nitrones. Stabilized and non-stabilized azomethine ylide dipoles or the related nitrones were generated by condensation of 4-, 5- or 6-halo-aldehydes with a readily available amino-acid, amino-ester or hydroxylamine to give an imine followed by cyclization and either decarboxylation or loss of a proton. After intermolecular cycloaddition with an activated dipolarophile, bicyclic or polycyclic (if the ylide dipole and/or dipolarophile contain a ring) amines were produced. A short synthesis of the alkaloid (±)-crispine A was achieved based on this tandem/domino 3-component coupling chemistry.