132305-32-9

Basic information

• Product Name: 2-(2,2-Dichloro-1,1-dimethyl-ethoxy)-2-methyl-benzo[1,3]dioxin-4-one
• Synonyms: 2-(2,2-Dichloro-1,1-dimethyl-ethoxy)-2-methyl-benzo[1,3]dioxin-4-one
• CAS NO: 132305-32-9
• Molecular Weight: 305.158
• Mol File: 132305-32-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2,2-Dichloro-1,1-dimethyl-ethoxy)-2-methyl-benzo[1,3]dioxin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,2-Dichloro-1,1-dimethyl-ethoxy)-2-methyl-benzo[1,3]dioxin-4-one(132305-32-9)
• EPA Substance Registry System: 2-(2,2-Dichloro-1,1-dimethyl-ethoxy)-2-methyl-benzo[1,3]dioxin-4-one(132305-32-9)

Safety Data

• Hazardous Substances Data: 132305-32-9(Hazardous Substances Data)

Upstream product

• 4773-53-9 1,1-dichloro-2-hydroxy-2-methylpropane 
• 5538-51-2 O-acetylsalicyloyl chloride 

Downstream Products

• 69-72-7 salicylic acid 
• 50-78-2 aspirin 

Relevant articles and documents

Aspirin prodrugs: synthesis of 2-substituted 2-methyl-4H-1,3-benzodioxin-4-ones and their screening for prodrug potential.

A series of new 2-substituted 2-methyl-4H-1,3-benzodioxin-4-ones 1 have been synthesized and fully characterized. This study involves fifteen compounds of which fourteen are orthoesters, containing tertiary aliphatic alkoxy groups. One compound contains a tert-butylperoxy group and one a 3 beta-cholesteryloxy group in the 2-position. The hydrolysis of these compounds 1 was followed in enzymatic and non-enzymatic media to clarify whether they are true prodrugs of aspirin. Two compounds 1 were additionally tested in vivo as potential topical keratolytics.