132338-33-1

Basic information

• Product Name: 2-hydroxy-4-methoxyacetophenone ethoxycarbonylhydrazone
• Synonyms: 2-hydroxy-4-methoxyacetophenone ethoxycarbonylhydrazone
• CAS NO: 132338-33-1
• Molecular Weight: 252.27
• Mol File: 132338-33-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-4-methoxyacetophenone ethoxycarbonylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-4-methoxyacetophenone ethoxycarbonylhydrazone(132338-33-1)
• EPA Substance Registry System: 2-hydroxy-4-methoxyacetophenone ethoxycarbonylhydrazone(132338-33-1)

Safety Data

• Hazardous Substances Data: 132338-33-1(Hazardous Substances Data)

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 4114-31-2 ethylhydrazine carboxylate 

Downstream Products

• 174813-44-6 2-(4-Chloro-2-fluoro-5-hydroxy-phenyl)-6-methoxy-3-methylene-2,3-dihydro-isoindol-1-one 
• 132338-35-3 2-Acetyl-5-methoxy-benzoic acid ethyl ester 

Relevant articles and documents

Synthesis and evaluation of novel benzofuran derivatives as selective SIRT2 inhibitors

A series of benzofuran derivatives were designed and synthesized, and their inhibitory activites were measured against the SIRT1-3. The enzymatic assay showed that all the compounds showed certain anti-SIRT2 activity and selective over SIRT1 and SIRT3 with IC50 (half maximal inhibitory concentration) values at the micromolar level. The preliminary structure-activity relationships were analyzed and the binding features of compound 7e (IC50 3.81 μM) was predicted using the CDOCKER program. The results of this research could provide informative guidance for further optimizing benzofuran derivatives as potent SIRT2 inhibitors.

Synthesis of o-acylarylcarboxylic esters: A new replacement of phenolic hydroxyl by a carbonyl group

A wide variety of the title esters are prepared in good yields via a new two step replacement of phenolic hydroxyl by an ethoxycarbonyl group.