1323421-18-6

Basic information

• Product Name: C₂₂H₂₀ClNO₃S₂
• CAS NO: 1323421-18-6
• Molecular Weight: 445.991
• Mol File: 1323421-18-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₀ClNO₃S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₀ClNO₃S₂(1323421-18-6)
• EPA Substance Registry System: C₂₂H₂₀ClNO₃S₂(1323421-18-6)

Safety Data

• Hazardous Substances Data: 1323421-18-6(Hazardous Substances Data)

Upstream product

• 4279-77-0 S-phenyl hydrogen thiomalonate 
• 3157-65-1 N-(p-chlorobenzylidene)-p-toluenesulfonamide 

Relevant articles and documents

Expanding the utility of Bronsted base catalysis: Biomimetic enantioselective decarboxylative reactions

As a result of the low reactivity of simple esters, the use of them as nucleophiles in direct asymmetric transformations is a long-standing challenge in synthetic organic chemistry. Nature approaches this difficulty through a decarboxylative mechanism, which is used for polyketide synthesis. Inspired by nature, we report guanidine-catalyzed biomimetic decarboxylative C-C and C-N bond-formation reactions. These highly enantioselective decarboxylative Mannich and amination reactions utilized malonic acid half thioesters as simple ester surrogates. It is proposed that nucleophilic addition precedes decarboxylation in the mechanism, which has been investigated in detail through the identification of intermediates by using electrospray ionization (ESI) mass-spectrometric analysis and DFT calculations. Copyright