132351-73-6

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-7-(phenylmethoxy)-
• CAS NO: 132351-73-6
• Molecular Formula: C23H18O4
• Molecular Weight: 358.394
• Mol File: 132351-73-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-7-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-7-(phenylmethoxy)-(132351-73-6)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-7-(phenylmethoxy)-(132351-73-6)

Safety Data

• Hazardous Substances Data: 132351-73-6(Hazardous Substances Data)

Upstream product

• 132351-65-6 7-benzyloxy-2-(4-methoxy-phenyl)-chroman-4-one 
• 100-09-4 4-methoxybenzoic acid 
• 76937-63-8 1-(4-Benzyloxy-2-hydroxy-phenyl)-3-(4-methoxy-phenyl)-propane-1,3-dione 
• 81674-92-2 (E)-1-(4-(benzyloxy)-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 29682-12-0 1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone 

Downstream Products

• 1415657-55-4 4-(2-hydroxy-4-benzyloxyphenyl)-6-(4-methoxyphenyl)-2-aminopyrimidine 
• 2196-14-7 7,4'-Dihydroxyflavon 

Relevant articles and documents

Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents

A novel series of 4,6-diaryl-2-aminopyrimidines 8a-o has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61-9.53 μg/mL. These compounds are several times more potent than chloroquine and quinine, the two standard drugs used for the purpose of comparison.

Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives

A series of chrysin derivatives were prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin production. Chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone and 2,6-dihydroxyacetophenone in 2 to 4 steps, respectively. Methxoylated chrysin derivatives were converted to the corresponding hydroxylated chrysin derivatives by the reaction with BBr 3 in good yields. The inhibitory activity of the chrysin derivatives against prostaglandin production from lipopolysaccharide-treated RAW 264.7 cells was measured. We found that chrysin derivatives with 3′,4′- dichloro substituents (5e, 6e and 7e) exhibited good inhibitory activity of prostaglandin production.

ONE-STEP CONVERSION OF FLAVANONES INTO ISOFLAVANONES: A NEW FACILE BIOMIMETIC SYNTHESIS OF ISOFLAVONES

One-step chemical conversion of flavanones into isoflavones by use of thallium trinitrate (TTN) is reported, and the mechanism of a 2,3-aryl migration in this reaction is discussed in relation to in vivo rearrangement process of flavanone precursors in the isoflavone biosynthesis.