132396-03-3Relevant articles and documents
Synthesis and Regiospecificity in Methylation of Pyridopyrazinium-1- and 3-olates and Pyridopyridazinium-2- and 4-olates
Batori, Sandor,Messmer, Andras
, p. 1673 - 1680 (2007/10/02)
New methods have been developed for the synthesis of pyridopyrazinium-1- and 3-olates 5a-f, 9 and 1-thiolate 24 as well as of pyridopyridazinium-4- and 2-olates 14, 20.The methylation of these new compounds was studied by soft and hard methylating agents.Depending on the nature of the reagent used, the pyridopyrazinium-1-olates 5a-f gave NMe 22a-f and/or OMe 23a-f products, whereas the 3-olate 9 and both the 4- and 2-pyridazinium-olates 14, 20 afforded solely OMe compounds 10,15, 21.A selectivity rule for methylation is proposed.