132402-81-4

Basic information

• Product Name: 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-carboxythiazole
• Synonyms: 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-carboxythiazole
• CAS NO: 132402-81-4
• Molecular Weight: 348.423
• Mol File: 132402-81-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-carboxythiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-carboxythiazole(132402-81-4)
• EPA Substance Registry System: 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-carboxythiazole(132402-81-4)

Safety Data

• Hazardous Substances Data: 132402-81-4(Hazardous Substances Data)

Upstream product

• 132402-66-5 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline 
• 88463-18-7 (S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 132402-59-6 2(S)--3-phenylpropanimino ethyl ether 
• 132402-74-5 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonylthiazole 

Downstream Products

• 120853-17-0 lissoclinamide 5 
• 161006-68-4 C₃₈H₄₃N₇O₆S₂ 
• 161006-69-5 Boc-(S)-Phe-Thz-(S)-Pro-aThr-(R)-Val-Thz-OMe 
• 276680-02-5 Boc-(S)-Phe-Thz-Phe-Pro-OMe 
• 161006-71-9 (S)-2-{[2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazole-4-carbonyl]-amino}-3-phenyl-propionic acid methyl ester 

Relevant articles and documents

Concise synthesis of stereodefined, thiazole - Containing cyclic hexa- and octapeptide relatives of the Lissoclinums, via cyclooligomerisation reactions

The synthesis of a range of thiazole containing cyclic peptides using cyclooligomerisation reactions of amino acid substituted thiazole monomers and by macrolactamisation procedures is reported. The synthetic approaches lead to high yields of novel 18- and 24-membered ring analogues of the naturally occurring Lissoclinum families of cyclic peptides found in marine organisms and algae.

Total Synthesis of Lissoclinamide 5, a Cytotoxic Cyclic Peptide from the Tunicate Lissoclinum patella

A total synthesis of lissoclinamide 5, and some of its stereoisomers, shows that its stereostructure should be revised to 13.