1324055-93-7Relevant articles and documents
A Synthesis of Spirooxindole-Isoindolinones Through Ugi Reaction Followed by Copper-Catalyzed Tandem C?N/C?C Coupling Process
Zhong, Xianqiang,Luo, Jianghao,Zhou, Wei,Cai, Qian
, p. 4969 - 4973 (2021)
A synthesis of spiroindolinone-isoindolinone skeletons is presented. The protocol is through a Ugi four-component reaction followed by highly efficient and mild copper-catalyzed intramolecular tandem C?N/C?C coupling process. Control experiments demonstra
Asymmetric Conjugate Addition of Ethylene Sulfonyl Fluorides to 3-Amido-2-oxindoles: Synthesis of Chiral Spirocyclic Oxindole Sultams
Chen, Jie,Huang, Bao-Qin,Wang, Zeng-Qing,Zhang, Xue-Jing,Yan, Ming
, p. 9742 - 9746 (2019/11/28)
An enantioselective conjugate addition of ethylene sulfonyl fluorides to 3-amido-2-oxindoles has been developed. Quinine-derived squaramides were identified as efficient catalysts. A series of spirocyclic oxindole sultams were prepared with excellent yields and enantioselectivities. A reaction mechanism via bifunctional activation was proposed.